Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists

A compound of Formula I:

• ##STR41## or a pharmaceutically acceptable salt form thereof wherein:
• W is --NR.sup.6 R.sup.6a ;
• Y is selected from --C(R.sup.7).sub.2 --, --C(.dbd.O)--, --S(O).sub.p --, --O--, --N(R.sup.6)--, --NR.sup.6 C(.dbd.O)--, --C(.dbd.O)N(R.sup.6)-- or a single bond;
• with the proviso that when n=0, then the bond between W and Y is not a heteroatom to heteroatom bond;
• with the proviso that when n=0 and W is NH.sub.2, then Y is not --C(.dbd.O)-- or --C(.dbd.O)N(R.sup.6)--;
• with the proviso that when n=1 and W is --NR.sup.6 R.sup.6a, then Y is not --S(O).sub.p --, --O--, --N(R.sup.6)--, or --NR.sup.6 C(.dbd.O)--;
• L.sup.1 is a bond;
• L.sup.2 is selected from:
• --(C.sub.1 to C.sub.4 alkyl)--, substituted with 0-8 R.sup.5b,
• --(C.sub.2 to C.sub.4 alkenyl)--, substituted with 0-6 R.sup.5b,
• --(C.sub.2 to C.sub.4 alkynyl)--, substituted with 0-4 R.sup.5b,
• --(cyclopropyl)--, substituted with 0-1 R.sup.5b,
• alternatively, L.sup.2 is taken together with R.sup.3 to form a benzo-fused ring, said benzo-fused ring being substituted with 0-1 R.sup.5 ;
• Z is selected from --C(.dbd.O)-- or --S(O).sub.p --;
• X is selected from --C(.dbd.O)--, --S(O).sub.p --, O, --N(R.sup.6)--, --NR.sup.6 C(.dbd.O)--, --C(.dbd.O)N(R.sup.6)--, or a single bond;
• A is selected from CO.sub.2 R.sup.9, SO.sub.3 H, tetrazolyl, or PO.sub.3 H;
• R.sup.1, R.sup.2, R.sup.3, R.sup.4, and R.sup.7 are independently selected from:
• H,
• C.sub.1 to C.sub.8 alkyl substituted with 0-5 R.sup.5,
• C.sub.2 to C.sub.8 alkenyl substituted with 0-5 R.sup.5
• C.sub.3 to C.sub.8 alkynyl substituted with 0-5 R.sup.5,
• C.sub.3 to C.sub.8 cycloalkyl substituted with 0-5 R.sup.5,
• C.sub.4 to C.sub.8 cycloalkylalkyl substituted with 0-5 R.sup.5,
• C.sub.7 to C.sub.11 arylalkyl substituted with 0-5 R.sup.5,
• C.sub. to C.sub.4 alkoxy substituted with 0-5 R.sup.5,
• aryl substituted with 0-5 R.sup.5 ;
• a 5-10-membered heterocyclic ring system containing 1-4 heteroatoms independently selected from N, S, and O, said heterocyclic ring being substituted with 0-4 R.sup.5 ;
• F, Cl, Br, I, CF.sub.3, CO.sub.2 R.sup.5a, C(.dbd.O)R.sup.5a, CONHR.sup.5a, CON(R.sup.5a).sub.2, OC(.dbd.O)R.sup.5a, OC(.dbd.O)OR.sup.5a, OR.sup.5a, OC(.dbd.O)N(R.sup.5a).sub.2, OCH.sub.2 co.sub.2 R.sup.5a, CO.sub.2 CH.sub.2 CO.sub.2 R.sup.5a, N(R.sup.5a).sub.2, NO.sub.2, NR.sup.5a C(.dbd.O)R.sup.5a, NR.sup.5a C(.dbd.O)OR.sup.5a, NR.sup.5a C(.dbd.O)N(R.sup.5a).sub.2, NR.sup.5a SO.sub.2 N(R.sup.5a).sub.2, NR.sup.5a SO.sub.2 R.sup.5a, S(O).sub.p R.sup.5a, or SO.sub.2 N(R.sup.5a).sub.2 ;
• alternatively, when m or n are 2-6, R.sup.7 can be taken together with R.sup.7 bonded to an adjacent carbon atom to form a direct bond, thereby to form a double or triple bond between the adjacent carbon atoms;
• R.sup.5 is selected independently from H, F, Cl, Br, I, CF.sub.3, CN, CHO, CO.sub.2 R.sup.5a, C(.dbd.O)R.sup.5a, CONHR.sup.5a, CON(R.sup.5a).sub.2, OC(.dbd.O)R.sup.5a, OC(.dbd.O)OR.sup.5a, OR.sup.5a, OC(.dbd.O)N(R.sup.5a).sub.2, OCH.sub.2 CO.sub.2 R.sup.5a, CO.sub.2 CH.sub.2 CO.sub.2 R.sup.5a, N(R.sup.5a).sub.2, NO.sub.2, NR.sup.5a C(.dbd.O)R.sup.5a, NR.sup.5a C(.dbd.O)OR.sup.5a, NR.sup.5a C(.dbd.O)N(R.sup.5a).sub.2, NR.sup.5a SO.sub.2 N(R.sup.5a).sub.2, NR.sup.5a SO.sub.2 R.sup.5a, S(O).sub.p R.sup.5a, or SO.sub.2 N(R.sup.5a).sub.2, C.sub.1 to C.sub.8 alkyl, C.sub.2 to C.sub.6 alkenyl, C.sub.3 to C.sub.11 cycloalkyl, C.sub.4 to C.sub.11 cycloalkylmethyl, C.sub.6 to C.sub.10 aryl, or C.sub.7 to C.sub.11 arylalkyl,
• R.sup.5b is selected independently from H, F, Cl, Br, I, CF.sub.3, CN, CHO, CO.sub.2 R.sup.5a, C(.dbd.O)R.sup.5a, CONHR.sup.5a, CON(R.sup.5a).sub.2, OC(.dbd.)R.sup.5a, OC(.dbd.O)OR.sup.5a, OR.sup.5a, OC(.dbd.O)N(R.sup.5a).sub.2, OCH.sub.2 CO.sub.2 R.sup.5a, CO.sub.2 CH.sub.2 CO.sub.2 R.sup.5a, N(R.sup.5a)2, NO.sub.2 NR.sup.5a C(O.dbd.O)R.sup.5a, NR.sup.5a C(.dbd.O)OR.sup.5a, NR.sup.5a C(.dbd.O)N(R.sup.5a).sub.2, C.sub.1 to C.sub.8 alkyl, C.sub.2 to C.sub.C.sub.6 alkenyl, C.sub.3 to C.sub.11 cycloalkyl, C.sub.4 C.sub.11 cycloalkylmethyl, C.sub.6 to C.sub.10 aryl, or C.sub.7 to C.sub.11 arylalkyl;
• OC(.dbd.O)R.sup.5a, OC(.dbd.O)OR.sup.5a, OR.sup.5a, OC(.dbd.O)N(R.sup.5a).sub.2, OCH.sub.2 CO.sub.2 R.sup.5a, CO.sub.2 CH.sub.2 CO.sub.2 R.sup.5a, N(R.sup.5a).sub.2, NO.sub.2, NR.sup.5a C(.dbd.O) R.sup.5a, NR.sup.5a C(.dbd.O) OR.sup.5a, NR.sup.5a C(.dbd.O)N(R.sup.5a).sub.2, NR.sup.5a SO.sub.2 N(R.sup.5a).sub.2, NR.sup.5a SO.sub.2 R.sup.5a, S(O).sub.p R.sup.5a, or SO.sub.2 N(R.sup.5a).sub.2, C.sub.1 to C.sub.8 alkyl, C.sub.2 to C.sub.6 alkenyl, C.sub.3 to C.sub.11 cycloalkyl, C.sub.4 to C.sub.11 cycloalkylmethyl, C.sub.6 to C.sub.11 aryl, or C.sub.7 to C.sub.11 arylalkyl;
• alternatively, two R.sup.5b groups when attached to adjacent carbon atoms may be taken together to form --CH.sub.2 --, thereby to form a cyclopropylene group;
• R.sup.5a is selected from:
• H, C.sub.1 to C.sub.8 alkyl, C.sub.2 to C.sub.6 alkenyl, C.sub.3 to C.sub.11 cycloalkyl, C.sub.4 to C.sub.11 cycloalkylmethyl, C.sub.6 to C.sub.10 aryl, or C.sub.7 to C.sub.11 arylalkyl;
• p1 R.sup.6, R.sup.6a, and R.sup.8 are independently selected from:
• H, C.sub.1 to C.sub.4 alkyl, C.sub.3 to C.sub.11 cycloalkyl, C.sub.6 to C.sub.10 aryl, C.sub.7 to C.sub.11 arylalkyl, C.sub.2 to C.sub.7 alkylcarbonyl, C.sub.7 to C.sub.11 arylcarbonyl, C.sub.2 to C.sub.11 alkoxycarbonyl, C.sub.4 to C.sub.11 cycloalkoxycarbonyl, C.sub.7 to C.sub.11 bicycloalkoxycarbonyl, or C.sub.7 to C.sub.11 aryloxycarbonyl;
• R.sup.9 is selected from H, C.sub.1 to C.sub.8 alkyl, C.sub.3 to C.sub.11 cycloalkyl, C.sub.6 to C.sub.10 aryl, C.sub.7 to C.sub.11 aralkyl, C.sub.3 to C.sub.10 alkylcarbonyloxyalkyl, C.sub.3 to C.sub.10 alkoxycarbonyloxyalkyl, C.sub.2 to C.sub.10 alkoxycarbonyl, C.sub.5 to C.sub.10 cycloalkylcarbonyloxyalkyl, C.sub.5 to C.sub.10 cycloalkoxycarbonyloxyalkyl, C.sub.5 to C.sub.10 cycloalkoxycarbonyl, C.sub.7 to C.sub.11 aryloxycarbonyl, C.sub.8 to C.sub.12 aryloxycarbonyloxyalkyl, C.sub.8 to C.sub.12 arylcarbonyloxyalkyl, C.sub.5 to C.sub.10 alkoxyalkylcarbonyloxyalkyl, C.sub.5 to C.sub.10 (5-alkyl-1,3-dioxa-cyclopenten-2-one-yl)methyl, or C.sub.10 to C.sub.14 (5-aryl-1,3-dioxa-cyclopenten-2-one-yl)methyl;
• m is an integer from 1-6, with the proviso that m plus n cannot be greater than 6;
• n is an integer from an integer from 0 to 6;
• p is an integer from 0 to 2.