Compositions and methods for delivery of genetic material

A pharmaceutical kit comprising:

• i) a first container that comprises DNA molecules dissociated from infectious agents, said DNA molecules comprising a nucleotide sequence which encodes a protein selected from the group consisting of:
• a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen;
• a protein which comprises an epitope identical or substantially similar to an epitope of a protein associated with hyperproliferating cells;
• a protein which comprises an epitope identical or substantially similar to an epitope of a protein associated with cells that characterize an autoimmune disease;
• and
• ii) a second container that comprises a saponin.

A method of immunizing an individual comprising the steps of:

• injecting into tissue of said individual at a site on said individual's body, saponin and a DNA molecule that comprises a DNA sequence that encodes a protein,
• wherein said DNA sequence is operatively linked to regulatory sequences which control the expression of said DNA sequence in cells of said individual;
• and
• wherein said DNA molecule is dissociated from an infectious agent and is taken up by cells in said tissue, said DNA sequence is expressed in said cells and an immune response is generated against said protein.