Prolonged release of biologically active polypeptides
AssigneeMonsanto Company
InventorJames W. Mitchell
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Abstract
Prolonged parenteral release of a bioactive polypeptide at desirably effective levels can be achieved using novel compositions in which the polypeptide is present in a biocompatible oil in an unusually high proportion such as at least about 10% by weight. Also disclosed are certain metal-associated somatotropins that are useful for prolonged parenteral release of such somatotropins.
Claims9
A substantially non-aqueous composition comprising at least about 10% by weight of a biologically-active somatotropin polypeptide and, as a continuous phase of said composition, a biocompatible oil, the composition effective upon administration for forming parenterally in an animal a sustained-release depot releasing somatotropin for a period of at least about seven days.
Dependencies are inferred from the claim text.