Methods of enhancing antigen-specific T cell responses
AssigneeSolis Therapeutics, Inc.
InventorsWilliam S. Robinson, Keting Chu
Life of this patent
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Abstract
Recombinant polynucleotides are provided that confer at least partial immunity on an individual to an infectious intracellular pathogenic agent. The recombinant polynucleotides encode a costimulatory factor and/or a target antigen polypeptide. The immune response that confers the immunity results from the expression of both polypeptides in an antigen presenting cell in the individual. The immunity is to the pathogenic agent that naturally encodes the target antigen polypeptide.
Claims15
A method of enhancing an antigen-specific T cell response in an individual to a target antigen comprising administering at least one polynucleotide sequence encoding at least one target antigen or a portion of the target antigen and at least one polynucleotide sequence encoding at least one B7 costimulatory molecule that interacts with T cell surface molecules for T cell activation, said polynucleotide sequences expressed in an amount effective to enhance a T cell response to eliminate cells bearing said target antigen or portion thereof, when said polynucleotide sequence encoding the target antigen and said polynucleotide sequence encoding the B7 costimulatory molecule are expressed in said individual.
A vector comprising at least one polynucleotide sequence encoding at least one target antigen or encoding a portion of said target antigen and at least one polynucleotide sequence encoding at least one B7 costimulatory molecule that interacts with T cell surface molecules for T cell activation when said B7 costimulatory molecule and said antigen are both expressed in an individual, wherein said polynucleotide sequences are expressed in an amount effective to enhance the T cell response to eliminate cells bearing said target antigen or portion thereof, and wherein said polynucleotide sequence encoding the target antigen is operably linked to a transcriptional control region and said polynucleotide sequence encoding the B7 costimulatory molecule is operably linked to a transcriptional control region for expression in said individual.
Dependencies are inferred from the claim text.