Optical biosensor matrix

A cell array plate comprising:

• a microtitre sample plate having a matrix of bores extending from a first surface of said sample plate through said sample plate and to an opposite second surface of said sample plate, the bores being arranged in rows and columns;
• a base plate arrangement having first and second opposite surfaces, and extending along said second opposite surface of said sample plate, said first surface of said base plate arrangement being in intimate contact with said opposite surface of said sample plate so as to seal said bores of said matrix along said opposite second surface of said sample plate, thereby closing said bores at a plurality of distinct surface areas;
• and
• a waveguiding film arrangement at said base plate arrangement and extending along said distinct surface areas, said base plate arrangement being transparent for light from said second surface of said base plate arrangement to said waveguiding film arrangement;
• said base plate arrangement comprising at least one diffraction grating structure area adjacent each of said plurality of distinct surface areas for coupling light impinging through said second surface of said base plate arrangement into said waveguiding film arrangement along a distinct surface area, and from said waveguiding film arrangement adjacent said distinct surface area, back through said second surface of said base plate arrangement;
• said base plate arrangement with said waveguiding film arrangement and said diffraction grating structure areas, substantially preventing light coupled into said waveguiding film arrangement at one of said plurality of distinct surface areas, from propagating into the waveguiding film arrangement at another one of said distinct surface areas neighboring said one of said distinct surface areas, and thereby substantially preventing cross-talk between said distinct surface areas.