Vectors and prokaryotes which autocatalytically delete antibiotic resistance
AssigneeMedImmune, LLC
InventorsShirley L. Haun, Charles K. Stover, Graham Hatfull, Mark S. Hanson, William R. Jacobs
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Abstract
A vector and a prokaryote transformed therewith which includes nucleic acid sequences which make possible the autocatalytic deletion of nucleotide sequences encoding an antibiotic resistance phenotype. The prokaryote can be a bacterium, and in particular a mycobacterium. Such transformed mycobacteria may be employed in vaccines, thereby eliminating the attendant risk of vaccines including antibiotic resistance markers.
Claims14
A vector comprising a nucleotide sequence encoding an antibiotic resistance phenotype flanked by res sites.
A vector comprising nucleotide sequences encoding an attP site, and integrase and resolvase.
Dependencies are inferred from the claim text.