Taga gene and methods for detecting predisposition to peptic ulceration and gastric carcinoma

A method of detecting the presence of a Helicobacter pylori strain possessing the 120-128 kilodalton antigen in a subject, comprising the steps of:

• a. contacting an antibody-containing sample from the subject with a detectable amount of a polypeptide consistinq of the amino acids encoded by nucleotides 1921 through 3648 contained in the nucleotide sequence defined in the Sequence Listinq as SEQ ID NO:1;
• and
• b. detecting the binding of the polypeptide and the antibody, the binding indicating the presence of the Helicobacter pylori strain.

A method of determining predisposition to peptic ulceration in a subject, comprising the steps of:

• a. contacting an antibody-containing sample from the subject with a detectable amount of a polypeptide consistinq of the amino acids encoded by nucleotides 1072 through 3645 contained in the nucleotide sequence defined in the Sequence Listing as SEQ ID NO:1;
• and
• b. detecting the binding of the polypeptide and the antibody, the binding indicating a predisposition of the subject to peptic ulceration.

A method of determining predisposition to peptic ulceration in a subject, comprising the steps of:

• a. contacting an antibody-containing sample from the subject with a detectable amount of a polypeptide consisting of the amino acids encoded by nucleotides 1921 through 3648 contained in the nucleotide sequence defined in the Sequence Listing as SEQ ID NO:1;
• and
• b. detecting the binding of the polypeptide and the antibody, the binding indicating a predisposition of the subject to peptic ulceration.

A method of determining predisposition to gastric carcinoma in a subject, comprising the steps of:

• a. contacting an antibody-containing sample from the subject with a detectable amount of a polypeptide consisting of the amino acids encoded by nucleotides 1072 through 3648 contained in the nucleotide sequence defined in the Sequence Listing as SEQ ID NO:1;
• and
• b. detecting the binding of the polypeptide and the antibody, the binding indicating a predisposition of the subject to gastric carcinoma.

A method of determining predisposition to gastric carcinoma in a subject, comprising the steps of:

• a. contacting an antibody-containing sample from the subject with a detectable amount of a polypeptide consisting of the amino acids encoded by nucleotides 1921 through 3648 contained in the nucleotide sequence defined in the Sequence Listing as SEQ ID NO:1;
• and
• b. detecting the binding of the polypeptide and the antibody, the binding indicating a predisposition of the subject to gastric carcinoma.