Controlled release of antiparasitic agents in animals
AssigneeAlkermes Controlled Therapeutics Inc. II
InventorDanny H. Lewis
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Abstract
A delivery system for providing antiparasitic agents to animals is provided and a method of treating parasitic infections in animals using such delivery systems is described. The delivery system is particularly useful for treatment with avermectins and milbemycins in lactide/glycolide polymeric matrices.
Claims29
An injectable controlled-release composition comprising:
- microparticles, wherein said microparticles comprise a biodegradable polymeric matrix, wherein said composition comprises an antiparasitic agent within said matrix, and wherein release of said agent is essentially dependent upon diffusion from, leaching from or erosion of the matrix or by a combination of these mechanisms.
An injectable controlled-release composition comprising microparticles, wherein said microparticles comprise a biodegradable polymeric matrix, wherein said composition comprises two or more antiparasitic agents, and wherein each of said agents is separately microencapsulated in said polymeric matrix such that each of said microparticles contains a single antiparasitic agent.
An injectable controlled-release composition comprising microparticles, wherein said microparticles comprise a biodegradable polymeric matrix, wherein said composition comprises two or more antiparasitic agents, wherein all of said antiparasitic agents is co-microencapsulated in said polymeric matrix such that each of said microparticles contains each of said antiparasitic agents, and wherein release of said agents is essentially dependent upon diffusion from, leaching from or erosion of the matrix, or a combination of these mechanisms.
Dependencies are inferred from the claim text.