Platelet glue wound sealant
AssigneeQuantic Biomedical Partners
InventorAndrew G. Hood, III
Life of this patent
Estimating the term…
Abstract
A plasma-buffy coat concentrate that comprises plasma, platelets at a concentration of at least 1.0.times.10.sup.9 cells/ml, and fibrinogen at concentration of at least 5 mg/ml is described. The plasma-buffy coat concentrate can be combined with a fibrinogen activator to form a platelet glue wound sealant. A method for processing blood to produce the plasma-buffy coat concentrate is also provided. The method comprises centrifuging anticoagulated blood to remove red blood cells and produce a plasma-buffy coat mixture. Water is removed from the mixture to produce the plasma-buffy coat concentrate. A fibrinogen activator is mixed with the plasma-buffy coat concentrate to produce a wound sealant, which can then be applied to a wound to facilitate sealing and healing of the wound.
Claims19
A plasma-buffy coat concentrate comprising:
- a. plasma;
- b. platelets at a concentration of at least 1.0.times.10.sup.9 cells/ml;
- c. fibrinogen at concentration of at least 5 mg/ml;
- and
- d. white cells at a concentration of at least 3.0.times.10.sup.7 cells/ml.
A wound sealant comprising:
- a plasma;
- b. platelets at a concentration of at least 1.0.times.10.sup.9 cells/ml;
- c. fibrinogen at concentration of at least 5 mg/ml;
- d. white cells at a concentration of at least 3.0.times.10.sup.7 cells/ml;
- and
- e. a fibrinogen activator in a concentration sufficient to initiate clot formation.
A method for processing blood comprising:
- a. centrifugally fractionating anticoagulated blood to remove red blood cells and produce a plasma-buffy coat mixture;
- and
- b. hemoconcentrating the plasma-buffy coat mixture to remove water from the mixture to produce a plasma-buffy coat concentrate.
A method of promoting wound sealing comprising:
- a. centrifugally fractionating anticoagulated blood to remove red blood cells and produce a plasma-buffy coat mixture;
- b. hemoconcentrating the plasma-buffy coat mixture to remove water from the mixture to produce a plasma-buffy coat concentrate;
- c. mixing the plasma-buffy coat concentrate with a fibrinogen activator to produce a wound sealant;
- and
- d. applying the wound sealant to a damaged tissue.
Dependencies are inferred from the claim text.