Hydrocarbon oil/fluorochemical preparations and methods of use
AssigneeAlliance Pharmaceutical Corp.
InventorsLeo A. Trevino, Jean G. Riess, Luis A. Dellamary, Marie-Pierre Krafft, Thomas E. Tarara
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Abstract
Novel hydrocarbon oil/fluorochemical preparations and methods for their use are provided. The preparations, which preferably comprise a fluorophilic dispersing agent, may be in the form of hydrocarbon oil-in-fluorochemical dispersions or in the form of a multiple emulsion comprising a polar liquid continuous phase and are particularly useful for administering bioactive agents. In particular the preparations of the present invention may be used to control the bioavailability and improve the efficacy of lipophilic bioactive agents having limited solubility in an aqueous physiological environment.
Claims41
A hydrocarbon-based oil-in-fluorochemical preparation comprising:
- a disperse phase comprising at least one hydrocarbon-based oil;
- a continuous phase comprising at least one fluorochemical;
- and
- an effective dispersing amount of at least one fluorophilic dispersing agent.
A hydrocarbon-based oil-in-fluorochemical-in-polar liquid multiple emulsion comprising:
- an emulsified disperse phase comprising at least one hydrocarbon-based oil, at least one fluorochemical and at least one fluorophilic dispersing agent wherein said emulsified disperse phase comprises a discontinuous hydrocarbon-based oil phase;
- and
- a continuous phase comprising at least one polar liquid having at least one emulsifying agent dispersed therein.
A method for forming a hydrocarbon-based oil-in-fluorochemical dispersion comprising the steps of:
- combining at least one hydrocarbon-based oil with an effective dispersing amount of at least one fluorophilic dispersing agent and at least one fluorochemical to provide a dispersion preparation comprising a discontinuous hydrocarbon-based oil phase;
- and
- admixing said dispersion preparation to produce a hydrocarbon-based oil-in-fluorochemical dispersion.
A method for preparing a hydrocarbon-based oil-in-fluorochemical multiple emulsion comprising the steps of:
- combining at least one hydrocarbon-based oil with an effective dispersing amount of at least one fluorophilic dispersing agent, at least one fluorochemical, at least one polar liquid and at least one emulsifying agent to provide a multiple emulsion preparation;
- and
- admixing said emulsion preparation to form a multiple emulsion comprising an hydrocarbon-based oil-in-fluorochemical disperse phase and a polar liquid continuous phase.
A method for delivering a bioactive agent to a patient comprising:
- providing a bioactive preparation comprising a hydrocarbon-based oil-in-fluorochemical dispersion and at least one bioactive agent wherein said hydrocarbon-based oil-in-fluorochemical dispersion comprises an effective dispersing amount of at least one fluorophilic dispersing agent;
- and
- administering said bioactive preparation to a patient.
Dependencies are inferred from the claim text.