Methods and formulations for modulating the human sexual response

A composition comprising an orally administrable rapidly dissolving tablet comprising phentolamine hydrochloride in a pharmaceutically acceptable carrier, said tablet having a disintegration time of less than about twenty minutes.

In a method for modulating sexual response in a human by administering a vasodilator agent to blood circulation in an amount effective to permit increased blood flow to the genitalia, the improvement comprising modulating the sexual response by oral administration of a rapidly dissolving tablet comprising phentolamine mesylate, said tablet having a disintegration time of less than about twenty minutes and being capable of delivering to the blood circulation an amount of phentolamine mesylate effective to permit increased blood flow to the genitalia within about one hour after administration.

In a method for modulating sexual response in a human by administering a vasodilator agent to blood circulation in an amount effective to permit increased blood flow to the genitalia, the improvement comprising modulating the sexual response by the oral administration of a rapidly dissolving tablet comprising phentolamine hydrochloride, said tablet having a disintegration time of less than about twenty minutes and being capable of delivering to the blood circulation an amount of phentolamine hydrochloride effective to permit increased blood flow to the genitalia within about one hour after administration.

In a method for treating male impotence by administering a vasodilator to blood circulation in an amount effective to permit increased blood flow to the penis thereby improving erectile ability, the improvement comprising permitting increased blood flow to the penis by oral administration of a rapidly dissolving tablet comprising phentolamine mesylate, said tablet having a disintegration time of less than about twenty minutes and being capable of delivering to the blood circulation the amount of phentolamine mesylate effective to improve erectile ability within about one hour after administration.

In a method for treating male impotence by administering a vasodilator to blood circulation in an amount effective to permit increased blood flow to the penis thereby improving erectile ability, the improvement comprising permitting increased blood flow to the penis by oral administration of a rapidly dissolving tablet comprising phentolamine hydrochloride, said tablet having a disintegration time of less than about twenty minutes and being capable of delivering to the blood circulation the amount of phentolamine hydrochloride effective to improve erectile ability within one hour after administration.

In a method for treating male impotence by administering a vasodilator agent to blood circulation in an amount effective to permit increased blood flow to the penis on demand, the improvement comprising the oral administration of a vasodilator formulation, the formulation comprising, from about 20 mg to about 80 mg of phentolamine mesylate whereby improvement in erectile ability occurs within from about 10 minutes to about 30 minutes after oral administration of the vasodilator formulation.

A composition comprising an orally administrable rapidly dissolving tablet comprising 40 mg phentolamine mesylate and a pharmaceutically acceptable carrier, said tablet having a disintegration time of less than one minute.

A composition comprising an orally administrable rapidly dissolving tablet comprising 80 mg phentolamine mesylate in a pharmaceutically acceptable carrier, said tablet having a disintegration time of less than one minute.

A composition comprising an orally administrable rapidly dissolving tablet comprising 40 mg phentolamine hydrochloride in a pharmaceutically acceptable carrier, said tablet having a disintegration of less than one minute.

A composition comprising an orally administrable rapidly dissolving tablet comprising 80 mg phentolamine hydrochloride in a pharmaceutically acceptable carrier, said tablet having a disintegration time of less than one minute.