Recombinant equine herpesviruses
AssigneeSyntro Corporation
InventorsMark D. Cochran, Christina H. Chiang
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Abstract
The present invention relates to a non-naturally occurring, recombinant equine herpesvirus. The invention also relates to a recombinant equine herpesvirus capable of replication which comprises viral DNA from a species of equine herpesvirus and foreign DNA, the foreign DNA being inserted into the equine herpesviral DNA at a site which is not essential for replication of the equine herpesvirus. The invention also relates to DNA encoding the US2 protein of an equine herpesvirus. The invention relates to homology vectors for producing recombinant equine herpesviruses which produce recombinant equine herpesviruses by inserting foreign DNA into equine herpesviral DNA. The invention further relates to a method of producing a fetal-safe, live recombinant equine herpesvirus.
Claims23
A live recombinant equine herpesvirus 4 (EHV-4) which comprises the genomic DNA of equine herpesvirus 4 from which a DNA sequence encoding the EHV-4 homologue of herpes simplex virus 1 (HSV-1) US2 gene product has been deleted.
Dependencies are inferred from the claim text.