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US 5,730,990 AGranted
Non-antigenic amine derived polymers and polymer conjugates
AssigneeEnzon, Inc.
InventorsRichard B. Greenwald, Anthony Martinez, Annapurna Pendri
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Abstract
Substantially non-antigenic polymers containing pI and/or pH optimum modulating moieties are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also disclosed.
Claims17
A substantially non-antigenic polymer comprising the formula:
- R--B'--W--L
- wherein
- (R) is a water-soluble, substantially non-antigenic polymer residue;
- (B') is a secondary or tertiary amine when B' is a tertiary amine,
- (W) is a spacer moiety selected from the group consisting of straight or branched C.sub.1-4 alkyls, aralkyl, aryl and heteroaryl moieties, C(O)NHCH.sub.2 CH.sub.2 C(O) and CH.sub.2 C(O);
- when B' is a secondary amine, (W) is selected from the group consisting of aralkyl, aryl, heteroaryl moieties, C(O)NHCH.sub.2 CH.sub.2 C(O) and CH.sub.2 C(O);
- and
- (L) is selected from the group consisting of:
- OH;
- functional groups capable of reacting with amino groups;
- functional groups capable of reacting with carboxylic acid groups;
- functional groups capable of reacting with reactive carbonyl groups;
- and
- functional groups capable of reacting with mercapto groups.
11 more elements
Dependencies are inferred from the claim text.