Oral vaccine against gram negative bacterial infection
AssigneeNovavax, Inc.
InventorD. Craig Wright
Life of this patent
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Abstract
The present invention concerns an oral preparation useful as an immunizing agent or vaccine against gram negative bacterial infection. This oral preparation can also be used as a treatment for those infected with gam negative bacteria. The preparations can be used against any gram negative bacterial infection, including Escherichia coli, Shigella flexneri 2a, and Salmonella enteriditis.
Claims26
An oral vaccine preparation for generating anti-LPS antibodies for treating gram negative infection, said oral vaccine preparation comprising inactivated gram negative bacteria and a lipid vesicle encapsulated flavor masking agent, said lipid vesicle comprising a paucilamellar lipid vesicle having 2-8 lipid bilayers surrounding an amorphous central cavity, and said paucilamellar lipid vesicle comprising a non-phospholipid material as a primary lipid in the bilayers.
A method of providing treatment against gram negative bacterial infection comprising oral administration of an effective amount of an oral vaccine including as active components inactivated gram negative bacteria and a lipid vesicle encapsulated flavor masking agent, where said paucilamellar lipid vesicle comprises a paucilamellar lipid vesicle having 2-8 lipid bilayers surrounding an amorphous central cavity, and said paucilmellar lipid vesicles comprising non-phospholipid materials as a primary lipid in the bilayers.
Dependencies are inferred from the claim text.