Porous polymeric material with gradients

A macroporous material comprising a permanently porous polymeric matrix in the form of a non-gelled dried integral body having a thickness about 5 mm or more and having a first end and a second end disposed longitudinally from the first end, said macroporous material having an average pore size of from about 50 nm-15,000 nm, said permanently porous polymeric matrix having a property gradient extending from the first end of the integral body to the second end thereof, wherein the property gradient is selected from the group consisting of pore size distribution, chemical composition, and a combination thereof.