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US 5,728,388 AGranted
Method of cancer treatment
OwnerDavid S. Termaninventor
Life of this patent
Estimating the term…
Abstract
Treatment of solid tumors, including their metastases, without radiation, surgery or standard chemotherapeutic agents is described. Ex vivo stimulation of cells, selection of specific V.beta. subsets of stimulated cells and reinfusion of the V.beta. subsets of stimulated cells is employed for cancer therapy.
Claims32
A method for inducing a tumoricidal reaction in vivo comprising:
- a) obtaining a sample comprising tumor-sensitized lymphocytes, wherein bodily fluids are substantially absent from said sample;
- b) contacting said sample with one or more superantigens ex vivo in a medium substantially free from tumor cells or other source of tumor antigen to produce stimulated cells;
- and
- c) infusing said stimulated cells into a tumor-bearing host.
1 more element
A method of human cancer treatment comprising:
- a) providing a human cancer patient;
- b) obtaining a sample comprising tumor-sensitized lymphocytes from said patient, wherein bodily fluids are substantially absent from said sample;
- c) contacting said sample ex vivo with one or more superantigens in a medium substantially free from tumor cells or other source of tumor antigen to generate stimulated cells;
- and
- d) infusing said stimulated cells into said patient so as to induce an in vivo therapeutic, tumoricidal reaction.
2 more elements
Dependencies are inferred from the claim text.