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US 5,726,322 AGranted
1-benzenesulfonyl-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
AssigneeSanofi
InventorsAlain Di Malta, Loic Foulon, Georges Garcia, Dino Nisato, Richard Roux, Claudine Serradeil-Legal, Gerard Valette, Jean Wagnon
Life of this patent
Estimating the term…
Abstract
The invention relates to 1-Benzenesulfonyl-1,3-dihydroindol-2-one derivatives of the formula ##STR1## and their salts, where appropriate, to their preparation and to pharmaceutical compositions in which they are present. These compounds have an affinity for the vasopressin and/or ocytocin receptors.
Claims3
A compound of the formula:
- ##STR158## in which R.sub.1 and R.sub.2 are each independently a hydrogen, a hydroxy, a C.sub.1 -C.sub.4 -.omega.-halogenoalkoxy, a halogen, a C.sub.1 -C.sub.4 -alkyl, a trifluoromethyl, a C.sub.1 -C.sub.7 -alkoxy, a C.sub.1 -C.sub.4 -polyhalogenoalkoxy, a C.sub.2 -C.sub.4 -.omega.-hydroxyalkoxy, an .omega.-methoxyalkoxy in which the alkyl is C.sub.2 -C.sub.4, a C.sub.2 -C.sub.4 -.omega.-aminoalkoxy which is free or substituted by one or two C.sub.1 -C.sub.4 -alkyls, a C.sub.3 -C.sub.7 -cycloalkoxy, a cycloalkylmethoxy in which the cycloalkyl is C.sub.3 -C.sub.7, a phenoxy, a benzyloxy, a C.sub.1 -C.sub.4 -alkylthio, a phenylthio, a nitro, an amino which is free or substituted by one or two C.sub.1 -C.sub.4 -alkyls, a cyano, a C.sub.1 -C.sub.4 -acyl, a C.sub.1 -C.sub.4 -acyloxy, a C.sub.1 -C.sub.4 -alkylsulfonamido, a phenylsulfonamido, a C.sub.1 -C.sub.4 -alkylamido, a C.sub.1 -C.sub.4 -alkoxycarbonylamino or a ureido which is unsubstituted or substituted by a phenol or by one or two C.sub.1 -C.sub.4 -alkyls;
- and
- R.sub.3 and R.sub.4 together form a group --(CH.sub.2).sub.p X(CH.sub.2).sub.q -- in which p and q are integers whose sum can vary from 3 to 6 and X is oxygen or sulfur.
A compound of formula (II)":
- ##STR159## in which:
- R.sub.1 is a hydroxy, a C.sub.1 -C.sub.4 -.omega.-halogenoalkoxy, a halogen, a C.sub.1 -C.sub.4 -alkyl, a trifluoromethyl, a C.sub.1 -C.sub.7 -alkoxy, a C.sub.1 -C.sub.4 -polyhalogenoalkoxy, a C.sub.2 -C.sub.4 -.omega.-hydroxyalkoxy, an .omega.-methoxyalkoxy in which the alkyl is C.sub.2 -C.sub.4, a C.sub.2 -C.sub.4 -.omega.-aminoalkoxy which is free or substituted by one or two C.sub.1 -C.sub.4 alkyls, a C.sub.3 -C.sub.7 -cycloalkoxy, a cycloalkylmethoxy in which the cycloalkyl is C.sub.3 -C.sub.7 ;
- a phenoxy;
- a benzyloxy;
- a C.sub.1 -C.sub.4 -alkylthio;
- a phenylthio;
- a nitro;
- an amino which is free or substituted by one or two C.sub.1 -C.sub.4 -alkyls;
- a cyano;
- a C.sub.1 -C.sub.4 -acyl;
- a C.sub.1 -C.sub.4 -acyloxy;
- a C.sub.1 -C.sub.4 -alkylsulfonamido;
- a phenylsulfonamido;
- a C.sub.1 -C.sub.4 -alkylamido;
- a C.sub.1 -C.sub.4 -alkoxycarbonylamino;
- or a ureido which is unsubstituted or substituted by a phenyl or by one or two C.sub.1 -C.sub.4 -alkyls;
- R.sub.3 and R.sub.4 together form a group --(CH.sub.2).sub.p X(CH.sub.2).sub.q ;
- p and q are each an integer, it being possible for their sum to vary from 3 to 6;
- and
- X is oxygen or sulfur.
17 more elements
Dependencies are inferred from the claim text.