Methods of treating disease using sertoli cells an allografts or xenografts
AssigneeResearch Corporation Technologies, Inc.
InventorHelena P. Selawry
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Abstract
The present invention describes a method of treating a disease that results from a deficiency of a biological factor which includes administering to a mammal Sertoli cells and cells that produce the biological factor. In particular, the present invention describes a method of treating diabetes mellitus by transplanting pancreatic islet of Langerhans cells in conjunction with Sertoli cells to create an immunologically privileged site. A method of creating an immunologically privileged site in a mammal for cellular transplants is further described by the present invention. A pharmaceutical composition comprising Sertoli cells and cells that produce a biological factor is also provided.
Claims40
A method of treating a disease that results from a deficiency of a biological factor in a mammal wherein said method comprises administering Sertoli cells and a therapeutically effective amount of cells that produce said biological factor to a mammal in need of such treatment, wherein said Sertoli cells are administered in an amount effective to create an immunologically privileged site.
A method of treating diabetes mellitus in a mammal wherein said method comprises administering to a diabetic mammal Sertoli cells in an amount effective to create an immunologically privileged site and a therapeutically effective amount of pancreatic islet of Langerhans cells for release of insulin.
A method of creating an immunologically privileged site in a mammal wherein said method comprises transplanting isolated Sertoli cells into a mammal.
A method of increasing the recovery and proliferation of biological factor producing cells ex vivo comprising co-culturing said cells with Sertoli cells under conditions sufficient to achieve said increased recovery and proliferation.
Dependencies are inferred from the claim text.