Non-invasive calibration and categorization of individuals for subsequent non-invasive detection of biological compounds

A process of calibrating an individual in preparation for the non-invasive measurement of a biological compound across the skin of that individual, comprising the steps of:

• (a) determining the contribution of one or more skin parameters to the non-invasive measurement and (b) correcting for the contribution of the one or more skin parameters in the subsequent non-invasive measurement of the biological compound, wherein the skin parameters include at least one member selected from the group consisting of melanin, non-melanin chromophores, skin thickness, water content, fat content, temperature, blood flow, skin quality, skin elasticity, hair follicles, sebaceous glands, permeability, proteins, and amino acids, and wherein the subsequent non-invasive measurement of the biological compound requires non-ionizing radiation.