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US 5,723,632 AGranted
Total synthesis of antitumor acylfulvenes
AssigneesMGI Pharma, Inc., The Regents of the University of California
InventorTrevor C. McMorris
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Abstract
The present invention provides a method of synthesizing compounds of formula (I): ##STR1## wherein R and R' are independently (C.sub.1 -C.sub.4)alkyl.
Claims10
A method of synthesizing a compound of formula (V):
- ##STR30## wherein R' is (C.sub.1 -C.sub.4)alkyl;
- comprising the steps of coupling a cyclopentenone of formula (II):
- ##STR31## wherein R.sub.4 is --O--C(R.sub.9).sub.2 O(R.sub.9), wherein R.sub.9 is (C.sub.1 -C.sub.4)alkyl;
- with a cyclic carbonyl ylide dipole of formula (III):
- ##STR32## to form a compound of formula (IV):
- ##STR33## and treating compound (IV) with base to form a ketone of formula (V).
3 more elements
Dependencies are inferred from the claim text.