Compositions and methods for use of IL-12 as an adjuvant
AssigneesThe Trustees of the University of Pennsylvania, The Wistar Institute of Anatomy and Biology
InventorsPhillip Scott, Giorgio Trinchieri
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Abstract
Improved vaccine compositions and methods of making same are provided, which vaccines are characterized by an antigen from a pathogen and an effective adjuvanting amount of Interleukin-12. These IL-12 adjuvanted vaccines are capable of increasing the vaccinated host's cell mediated immune response to provide an increased and protective immune response to the pathogen. Also disclosed are methods for vaccinating hosts by administering a vaccine containing an antigen from a pathogenic microorganism and co-administering an adjuvanting amount of IL-12. Vaccines or therapeutic compositions directed against a cancer may also be adjuvanted with IL-12 according to this invention.
Claims8
An antigenic composition comprising a selected antigen from a pathogenic bacteria or virus and an effective adjuvanting amount of Interleukin-12, wherein said Interleukin-12 enhances the cell mediated immune response to said antigen.
A method for preparing an antigenic composition comprising adding to a composition containing an antigen from a pathogenic bacteria virus, an effective amount of Interleukin-12, said antigenic composition eliciting a stronger immune response in a host than elicited by administration of the antigen alone.
A method for increasing the ability of an antigenic composition containing an antigen from a pathogenic bacteria or virus to elicit the host's cell mediated immune response for an immune response against said pathogen or cancer comprising administering to a host simultaneously or sequentially with said antigenic composition, an effective amount of Interleukin-12.
A method for enhancing the immune response elicited by an antigenic composition comprising administering to a host simultaneously or sequentially with said antigenic composition, an effective amount of Interleukin-12.
An improved composition useful for eliciting an immune response to a selected pathogen, said composition comprising an antigen from said pathogen,
- wherein the improvement consists of including interleukin-12 in said composition, and wherein said interleukin-12-containing composition elicits an enhanced immune response to said pathogen.
Dependencies are inferred from the claim text.