Monoclonal antibodies directed to the HER2 receptor
AssigneeGenentech, Inc.
InventorsRobert M. Hudziak, H. Michael Shepard, Axel Ullrich, Brian M. Fendly
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Abstract
A method of inhibiting growth of tumor cells which overexpress a growth factor receptor or growth factor by treatment of the cells with antibodies which inhibit the growth factor receptor function, is disclosed. A method of treating tumor cells with antibodies which inhibit growth factor receptor function, and with cytotoxic factor(s) such as tumor necrosis factor, is also disclosed. By inhibiting growth factor receptor functions tumor cells are rendered more susceptible to cytotoxic factors.
Claims35
A method of treating a patient having a carcinoma that overexpresses HER2 receptor comprising administering to said patient a cytotoxic factor and an antibody which binds to the HER2 receptor, each in amounts effective to eliminate or reduce the patient's tumor burden, wherein said antibody sensitizes tumor cells that overexpress HER2 receptor to said cytotoxic factor.
A composition suitable for administration to a patient having a tumor that overexpresses HER2 receptor comprising (a) an antibody which binds to the HER2 receptor, and (b) a cytotoxic factor, each present in amounts effective to eliminate or reduce the patient's tumor burden upon administration of the composition to the patient, wherein said antibody sensitizes tumor cells that overexpress HER2 receptor to said cytotoxic factor.
Dependencies are inferred from the claim text.