Enzymatic process for the preparation of optically active tetralin derivatives
AssigneeSanofi
InventorsRoberto Cecchi, Laura Barzaghi, Umberto Guzzi
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Abstract
The present invention relates to an enzymatic process for the preparation of optically active tetrahydro-2-naphthoic acids from the corresponding racemic esters by reaction with a lipase.
Claims4
A compound of formula (II') ##STR12## in which R is a C.sub.1 -C.sub.3 -alkyl, which compound is in optically pure form in an enantiomeric excess above 90%, provided that the methoxy group is not in position 5 of the naphthalene ring.
A compound selected from the group consisting of:
- methyl 6-methoxy-1,2,3,4-tetrahydro-(2S)-2-naphthoate;
- methyl 7-methoxy-1,2,3,4-tetrahydro-(2S)-2-naphthoate;
- and
- methyl 8-methoxy-1,2,3,4-tetrahydro-(2S)-2-naphthoate,
- which compound is in optically pure form in an enantiomeric excess above 90%.
8-methoxy-1,2,3,4-tetrahydro-(2R)-2-naphthoic acid in optically pure form in an enantiomeric excess above 90%.
8-methoxy-1,2,3,4-tetrahydro-(2S)-2-naphthoic acid in optically pure form in an enantiomeric excess above 90%.
Dependencies are inferred from the claim text.