LTA.sub.4 hydrolase inhibitors

A compound of the Formula I:

• Ar.sup.1 --Q--Ar.sup.2 --Y--R--Z (I)
• or a pharmaceutically acceptable salt thereof, wherein:
• Ar.sup.1 is selected from the group consisting of phenyl, mono-, di-, or tri-substituted phenyl with the substituents selected from the group consisting of Cl, Br, F, CF.sub.3, lower alkyl, lower alkoxy, NH.sub.2, NO.sub.2 and OH;
• Ar.sup.2 is phenyl optionally substituted with R.sup.7, R.sup.8 and R.sup.9 wherein R.sup.7, R.sup.8, and R.sup.9 are H, lower alkyl, lower alkoxy, hydroxy, halogen, --NH.sub.2, and --NO.sub.2 ;
• Q is --O--, --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --, --CH.sub.2 --CH.sub.2 --CH.sub.2 --, --CF.sub.2 --, and --CH.sub.2 O--;
• Y is --O-- and --S--;
• R is linear or branched C.sub.2 -C.sub.6 alkenyl;
• and
• Z is ##STR729## wherein R.sup.1 is H, lower alkyl, or allyl, and R.sup.2 is --(CH.sub.2).sub.a COOR.sup.16, wherein R.sup.16 is H, lower alkyl and benzyl, and a is an integer of from 0 to 5.