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US 5,719,262 AGranted
Peptide nucleic acids having amino acid side chains
OwnerOle Buchardt, deceased, by Dorte Buchardt, legal representative +3inventors
InventorsOle Buchardt, deceased, by Dorte Buchardt, legal representative, Michael Egholm, Peter Eigil Nielsen, Rolf Henrik Berg
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Abstract
A novel class of compounds, known as peptide nucleic acids, bind complementary DNA and RNA strands more strongly than the corresponding DNA or RNA strands, and exhibit increased sequence specificity and solubility. The peptide nucleic acids comprise ligands selected from a group consisting of naturally-occurring nucleobases and non-naturally-occurring nucleobases attached to a polyamide backbone, and contain alkylamine side chains.
Claims11
A peptide nucleic acid having formula:
- ##STR3## wherein:
- each L is independently a naturally-occurring nucleobase or a non-naturally-occurring nucleobase;
- each R.sup.7' is independently hydrogen or C.sub.1 -C.sub.8 alkylamine, provided that at least one R.sup.7' is C.sub.1 -C.sub.8 alkylamine;
- R.sup.h is OH, NH.sub.2 or NHLysNH.sub.2 ;
- R.sup.i is H, COCH.sub.3 or t-butoxycarbonyl;
- and
- n is an integer from 1 to 30.
4 more elements
Dependencies are inferred from the claim text.