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US 5,719,197 AGranted
Compositions and methods for topical administration of pharmaceutically active agents
AssigneeNoven Pharmaceuticals, Inc.
InventorsDavid P. Kanios, Joseph A. Gentile, Juan A. Mantelle, Steven Sablotsky
Life of this patent
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Abstract
Compositions for topical application comprising a therapeutically effective amount of a pharmaceutical agent(s), a pharmaceutically acceptable bioadhesive carrier, a solvent for the pharmaceutical agent(s) in the carrier and a clay, and methods of administering the pharmaceutical agents to a mammal are disclosed.
Claims27
A flexible, finite, bioadhesive composition for topical application comprising:
- (a) a therapeutically effective amount of at least one pharmaceutically active agent;
- (b) a pharmaceutically acceptable solvent for the pharmaceutically active agent and a plasticizer;
- (c) in admixture with the pharmaceutically active agent in the solvent, a pharmaceutically acceptable bioadhesive carrier in an amount from about 5 to 50 percent based on the weight of the whole composition;
- and
- (d) a cohesive increasing amount of a clay;
- wherein the composition is substantially free of water, substantially water insoluble and is a bioadhesive;
- and wherein the pharmaceutically active agent is present in non-crystallized form in the composition.
4 more elements
Dependencies are inferred from the claim text.