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US 5,719,060 AGranted
Method and apparatus for desorption and ionization of analytes
AssigneeBaylor College of Medicine
InventorsT. William Hutchens, Tai-Tung Yip
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AssigneeBaylor College of Medicine
InventorsT. William Hutchens, Tai-Tung Yip
Estimating the term…
This invention relates generally to methods and apparatus for desorption and ionization of analytes for the purpose of subsequent scientific analysis by such methods, for example, as mass spectrometry or biosensors. More specifically, this invention relates to the field of mass spectrometry, especially to the type of matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry used to analyze macromolecules, such as proteins or biomolecules. Most specifically, this invention relates to the sample probe geometry, sample probe composition, and sample probe surface chemistries that enable the selective capture and desorption of analytes, including intact macromolecules, directly from the probe surface into the gas (vapor) phase without added chemical matrix.
A method for desorbing analyte molecules from a sample presenting surface, comprising:
The method according to claim or 1, wherein the binding is non-selective.
A method for preparing a sample probe for mass spectrometry for presenting analyte molecules for analysis, said method comprising:
A sample probe for promoting desorption of intact analytes into the gas phase comprising:
A sample probe for promoting differential desorption of intact analyte into the gas phase, comprising:
A sample probe for presenting an analyte to an energy source capable of desorbing the analyte from the probe, comprising:
Dependencies are inferred from the claim text.