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US 5,716,640 AGranted
Method of producing sustained-release microcapsules
AssigneeTakeda Chemical Industries, Ltd.
InventorsShigeru Kamei, Minoru Yamada, Yasuaki Ogawa
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AssigneeTakeda Chemical Industries, Ltd.
InventorsShigeru Kamei, Minoru Yamada, Yasuaki Ogawa
Estimating the term…
A method of producing sustained-release microcapsules containing a biologically active substance from an W/O emulsion comprising an inner aqueous phase containing said biologically active substance and an external oil phase containing a biodegradable polymer, characterized in that microcapsules formed on microencapsulation of said biologically active substance with said biodegradable polymer are heated at a temperature not lower than the glass transition temperature of said biodegradable polymer but not so high as to cause aggregation of the microcapsules. This method enables the production of very useful sustained release microcapsules adapted to release a bologically active substance at a calculated rate over a protracted time period starting immediately following administration without an initial burst within one day following administration.
A method of producing sustained-release microcapsules containing a biologically active substance from an W/O emulsion comprising an inner aqueous phase containing said biologically active substance and an external oil phase containing a biodegradable polymer, characterized in that microcapsules formed on microencapsulation of said biologically active substance with said biodegradable polymer are heated at a temperature not lower than the glass transition temperature of said biodegradable polymer but not so high as to cause aggregation of the microcapsules.
Sustained-release microcapsules containing a biologically active substance which is produced by heating microcapsules formed on microencapsulation of said biologically active substance with a biodegradable polymer at a temperature not lower than the glass transition temperature of said biodegradable polymer but not so high as to cause aggregation of the microcapsules.
A method of producing sustained-release microcapsules containing a biologically active substance from an W/O emulsion comprising an inner aqueous phase containing said biologically active substance and an external oil phase containing a biodegradable polymer, wherein microcapsules formed on microencapsulation of said biologically active substance with said biodegradable polymer are heated at a temperature between that which not lower than the glass transition temperature of said biodegradable polymer and a temperature 40.degree. C. higher than said the glass transition temperature.
Dependencies are inferred from the claim text.