Nonocclusive drug delivery device and process for its manufacture

A process for manufacturing a nonocclusive drug delivery device which comprises:

• a) bonding a substantially moisture vapor permeable, liquid impermeable, flexible thermoplastic barrier layer to the upper surface of an open cell, flexible, oleophilic thermoplastic foam layer possessing predetermined adhesive and drug depot zones;
• b) applying a first release liner possessing an opening and having a layer of contact adhesive upon its lower surface to the lower surface of the foam layer with the adhesive contacting and infiltrating the adhesive zone of the foam layer the opening in the release liner exposing a portion of the lower surface of the foam layer including the drug depot zone;
• c) introducing a predetermined quantity of drug composition comprising a drug and an oleophilic drug delivery vehicle into the exposed drug depot zone;
• d) removing the first release liner to expose the entire lower surface of the foam layer, the contact adhesive remaining within the adhesive zone of the foam layer;
• and,
• e) applying a second release liner to the lower surface of the foam layer to fully seal said surface.