Dietary and pharmaceutical compositions containing lyophilized lactic bacteria, their preparation and use
AssigneesRenata Maria Anna Cavaliere Vesely, Claudio De Simone
InventorsRenata Maria Anna Cavaliere Vesely, Claudio De Simone
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Abstract
A pharmaceutical composition containing several different bacteria including Streptococcus thermophilus, Lactobacilli and Bifidobacteria is disclosed. The bacteria are present in the composition at a total concentration of 1.times.10.sup.11 to 1.times.10.sup.13 per gram. Further, methods of using the pharmaceutical are disclosed which include treatment of a gastrointestinal disorder and hypercholesteremia. Also a method for modulating a host's immune response is disclosed.
Claims33
A pharmaceutical composition comprising:
- a) from 10% to 95% by weight of total composition of lyophilized Streptococcus thermophilus, and
- b) from 5% to 90% by weight of total composition of at least one lyophilized bacterium selected from the group consisting of Lactobacillus plantarum and Lactobacillus casei, and
- c) from 0% to 10% by weight of total composition a pharmaceutically acceptable excipient,
- wherein said Streptococcus thermophilus and the bacterium b) are present in a concentration of 1.times.10.sup.11 -1.times.10.sup.13 total bacteria per gram of the composition.
A pharmaceutical composition comprising:
- (a) from 30-35% by weight of lyophilized Streptococcus thermophilus;
- (b) from 7-10% by weight of lyophilized Lactobacillus casei;
- (c) from 8-10% by weight of lyophilized Lactobacillus plantarum;
- (d) from 7-10% by weight of lyophilized Lactobacillus acidophilus;
- (e) from 8-10% by weight of lyophilized Lactobacillus delbrueckii sub-species bulgaricus;
- (f) from 27-30% by weight of a mixture of lyophilized bifidobacteria;
- and
- (g) from 8-10% by weight of a pharmaceutically acceptable excipient,
- wherein all amounts are based on the total weight of the composition and said bifidobacteria is a mixture of Bifidobacterium longum, Bifidobacterium infantis, and Bifidobacterium bifidum;
- wherein said excipient is selected from the group consisting of maltodextrin, levulose, microcrystalline cellulose, maize starch, lactose, and dextrose;
- and
- wherein said Streptococcus thermophilus, said Lactobacillus casei, and said Lactobacillus plantarum are present in said pharmaceutical composition in a total concentration of 1.times.10.sup.11 to 1.times.10.sup.13 bacteria per gram.
A method for treating hypercholesteremia, comprising administering to a patient in need thereof an effective amount of a composition, said composition comprising:
- (a) from 10 to 95% by weight of total composition of lyophilized Streptococcus thermophilus;
- (b) from 5 to 90% by weight of total composition of at least one lyophilized bacteria selected from the group consisting of Lactobacillus plantarum and Lactobacillus casei;
- and
- (c) from 0 to 10% by weight of total composition of a pharmaceutically acceptable excipient;
- wherein said Streptococcus thermophilus, Lactobacillus plantarum, and Lactobacillus casei are present in such amounts that the total bacteria concentration in said composition is 1.times.10.sup.11 to 1.times.10.sup.13 total bacteria per gram of composition.
A method for treating a gastrointestinal disorder, comprising administering to a patient in need thereof an effective amount of a composition, said composition comprising:
- (a) from 10 to 95% by weight of total composition of lyophilized Streptococcus thermophilus;
- (b) from 5 to 90% by weight of total composition of at least one lyophilized bacteria selected from the group consisting of Lactobacillus plantarum and Lactobacillus casei;
- and
- (c) from 0 to 10% by weight of total composition of a pharmaceutically acceptable excipient;
- wherein said Streptococcus thermophilus, Lactobacillus plantarum, and Lactobacillus casei are present in such amounts that the total bacteria concentration in said composition is 1.times.10.sup.11 to 1.times.10.sup.13 total bacteria per gram of composition.
A method for modulating a host's immune response, comprising administering to a patient in need thereof an effective amount of a composition, said composition comprising:
- (a) from 10 to 95% by weight of total composition of lyophilized Streptococcus thermophilus;
- (b) from 5 to 90% by weight of total composition of at least one lyophilized bacteria selected from the group consisting of Lactobacillus plantarum and Lactobacillus casei;
- and
- (c) from 0 to 10% by weight of total composition of a pharmaceutically acceptable excipient;
- wherein said Streptococcus thermophilus, Lactobacillus plantarum, and Lactobacillus casei are present in such amounts that the total bacteria concentration in said composition is 1.times.10.sup.11 to 1.times.10.sup.13 total bacteria per gram of composition.
Dependencies are inferred from the claim text.