# US 5,716,611 A · Emollient antimicrobial formulations containing povidone iodine > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,716,611 A - Document ID: US5716611A - Status: Granted - Kind: A - Application number: 08/582,851 - Filed: 1996-01-02 - Granted: 1998-02-10 - Earliest claimed: 1996-01-02 - Assignees: Euro-Celtique S.A. - Inventors: Benjamin Oshlack; Mark Chasin; Richard Sackler; Dileep Bhagwat - Web page: https://patentgrep.com/patent/US5716611A ## CPC - A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)} - A01N 59/12: Iodine, e.g. iodophors; Compounds thereof - A61K 31/79: Polymers of vinyl pyrrolidone - A61K 33/18: Iodine; Compounds thereof - A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers - A61K 47/28: Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid - Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS - Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE ## Abstract Novel topical formulations an anti-microbially effective amount of povidone iodine and a water-washable emollient, as well as, methods for their preparation, are disclosed. ## Claims ### Claim 1 A topical formulation comprising: an anti-microbially effective amount of povidone iodine; and from 2% to about 30% of a water-soluble emollient comprising from about 1 to about 99% ethoxylated higher aliphatic alcohol and from about 1 to about 99% ethoxylated cholesterol derivative. ### Claim 2 (depends on 1) The topical formulation of claim 1, comprising from about 2 to about 20% povidone iodine. ### Claim 3 (depends on 1) The topical formulation of claim 1, comprising about 7.5% w/v of said povidone iodine; from about 2 to about 20% surfactant; and at least 5% to about 30% w/v water soluble emollient. ### Claim 4 (depends on 3) The topical formulation of claim 3, having a pH of from about 1.5 to about 6.5. ### Claim 5 (depends on 2) The topical formulation of claim 2, wherein said water-soluble emollient comprises from about 3 to about 5% of the formulation by weight. ### Claim 6 (depends on 1) The topical formulation of claim 1, wherein said povidone iodine is included in an amount which provides from about 1 to about 30% available iodine. ### Claim 7 (depends on 1) The topical formulation of claim 1, further comprising from about 0.5% to about 30% of a surfactant selected from the group consisting of ethoxylated higher aliphatic alcohol derivatives, ethanol amines reacted with fatty acids, and mixtures thereof. ### Claim 8 (depends on 1) The topical formulation of claim 1, further comprising a stabilizer selected from the group consisting of iodine, an iodine salt or a combination thereof. ### Claim 9 (depends on 4) The topical formulation of claim 4, further comprising a pH adjuster. ### Claim 10 (depends on 1) The topical formulation of claim 1, further comprising a viscosity agent. ### Claim 11 (depends on 1) The topical formulation of claim 1, further comprising a stabilizer comprising potassium iodate. ### Claim 12 (depends on 1) The topical formulation of claim 1, further comprising from about 0.1 to about 10% w/v of a fragrance. ### Claim 13 (depends on 1) The topical formulation of claim 1 which is contained within a high density polyethylene container. ### Claim 14 A method for preparing a topical formulation comprising the steps of: incorporating from about 1 to about 99% ethoxylated higher aliphatic alcohol and from about 1 to about 99% ethoxylated cholesterol derivative or into a solution comprising an anti-microbially effective amount of povidone iodine and greater than 2 to about 30% of a water-soluble emollient. ### Claim 15 (depends on 14) The method of claim 14, further comprising adjusting the pH of said formulation to from about 1.5 to about 6.5. ### Claim 16 A method of treating human skin, comprising the steps of: applying to human skin a topical formulation comprising an anti-microbially effective amount of an iodophor; and greater than 2% of a water-soluble emollient comprising from about 1 to about 99% ethoxylated higher aliphatic alcohol and from about 1 to about 99% ethoxylated cholesterol derivative. ### Claim 17 (depends on 16) The method of claim 16, wherein said iodophor is povidone iodine in an amount which provides from about 1 to about 30% available iodine in said formulation, and said emollient comprises an anti-microbially effective amount of povidone iodine and greater than 2 to about 30% of a water-soluble emollient comprising from about 1 to about 99% of an ethoxylated higher aliphatic alcohol and from about 1 to about 99% of an ethoxylated cholesterol derivative. ### Claim 18 In a topical formulation which contains an antimicrobially effective amount of povidone iodine, the improvement comprising incorporating into said formulation greater than 2% of a water-soluble emollient comprising from about 1 to about 99% ethoxylated higher aliphatic alcohol and from about 1 to about 99% ethoxylated cholesterol derivative. ### Claim 19 (depends on 18) The formulation of claim 18, wherein said water-soluble emollient is a combination of from about 2 to about 30% of a water-soluble emollient comprising from about 1 to about 99% of an ethoxylated higher aliphatic alcohol and from about 1 to about 99% of an ethoxylated cholesterol derivative.