Method for reduction of migraine headache pain
OwnerWilliam J. Binderinventor
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Abstract
The invention is a method for reducing headache pain and symptoms associated with the onset or occurrence of headache in mammals. The method is performed by delivering an invertebrate presynaptic neurotoxin to a mammal extramuscularly (preferably at a localized, site of pain), or at a site in one or more muscles (preferably muscles of the face, cranium and neck). The presynaptic neurotoxins administered according to the invention are those neurotoxins that are known to produce a reversible, flaccid paralysis of muscle tissue in mammals. The preferred neurotoxin for use in the method of the invention is Botulinum toxin, particularly Botulinum toxin A.
Claims21
A method for reduction of pain associated with a migraine headache in a mammal comprising administering a therapeutically effective amount of an invertebrate presynaptic neurotoxin in a pharmaceutically safe form to the mammal.
A method for reduction of symptoms associated with the onset or presence of a migraine headache in a mammal comprising administering a therapeutically effective amount of an invertebrate presynaptic neurotoxin in a pharmaceutically safe form to the mammal.
A method for reduction of pain associated with a migraine headache in a mammal comprising administering a therapeutically effective amount of an invertebrate presynaptic neurotoxin in a pharmaceutically safe form to the mammal by delivery of the presynaptic neurotoxin to an extramuscular site of the face, cranium or neck.
A method for reduction of symptoms associated with the onset or presence of a migraine headache in a mammal comprising administering a therapeutically effective amount of an invertebrate presynaptic neurotoxin in a pharmaceutically safe form to the mammal by delivery of the presynaptic neurotoxin to an extramuscular site in the face, cranium or neck.
Dependencies are inferred from the claim text.