Chimeric rhinoviruses
AssigneeRutgers University
InventorsEdward V. Arnold, Gail Ferstandig Arnold
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Abstract
Various novel recombinant chimeric human rhinoviruses are disclosed, including viruses comprising human rhinovirus 14 into which chimeric regions derived from influenza HA, poliovirus and HIV-1 have been incorporated. Chimeric human rhinoviruses are particularly advantageous as they are only mildly pathogenic, have numerous potential serotypes and can elicit significant mucosal and serum immunological response. Design considerations, methods, and examples are described. The chimeric rhinoviruses can be used as vaccines and for a variety of other immunotechnological applications including passive immunization, immunodiagnostic testing and antigenicity and immunogenicity studies.
Claims27
Biologically pure recombinant chimeric human rhinovirus constructed by inserting into the nucleotide sequence of a human rhinovirus encoding part of a neutralizing immunogenic site, a heterologous nucleotide sequence encoding a chimeric region, wherein the chimeric region is expressed on the surface of the chimeric rhinovirus and is capable of participating in an immune reaction.
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