Hybrid immunoglobulins
AssigneeGenentech, Inc.
InventorsDaniel J. Capon, Laurence A. Lasky
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Abstract
Novel polypeptides are provided, together with methods for making and using them, and nucleic acids encoding them. These polypeptides are useful as cell surface adhesion molecules and ligands, and are useful in therapeutic or diagnostic compositions and methods.
Claims9
A method for preventing attachment of a lymphocyte to an endothelial cell comprising contacting an endothelial cell with a chimeric molecule comprising a lymphocyte homing receptor (LHR) fused at its C-terminus to the N-terminus of an immunoglobulin constant region under conditions such that the chimeric molecule binds to the endothelial cell a prevents attachment of the lymphocyte.
Dependencies are inferred from the claim text.