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AssigneeCIBA Vision Corporation
InventorsHarald Bothe, Achim Muller, Bernhard Seiferling, Sharla Borghorst, John Golby, Peter Hagmann, Peter Herbrechtsmeier, Otto Kretzschmar
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The present invention describes novel statistical copolymers and the preparation and possible uses thereof. Copolymers are described that are water-soluble and cross-linkable and that comprise the copolymerisation product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond.
A cross-linkable copolymer comprising a copolymerization product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks in accordance with the Lewis-Mayo equation, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond, wherein the cross-linkable copolymer is water-soluble, and wherein the hydrophilic vinyl monomer (b) is selected from hydroxy-substituted lower alkyl acrylates and methacrylates, acrylamide, methacrylamide, lower alkyl-acrylamides and -methacrylamides, ethoxylated acrylates and methacrylates, hydroxy-substituted lower alkyl-acrylamides and -methacrylamides, hydroxy-substituted lower alkyl vinyl ethers, sodium ethylenesulfonate, sodium styrenesulfonate, 2-acrylamido-2-methylpropanesulfonic acid, N-vinylpyrrole, 2- and 4-vinylpyridine, vinylically unsaturated carboxylic acids having a total of from 3 to 5 carbon atoms, amino-lower alkyl, mono-lower alkyl and di-lower alkylamino-lower alkyl acrylates and methacrylates and allyl alcohol.
A cross-linkable copolymer comprising a copolymerization product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks in accordance with the Lewis-Mayo equation, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond, wherein the cross-linkable copolymer is water-soluble, and wherein the functional vinyl monomer (b) is selected from hydroxy-substituted lower alkyl acrylates and methacrylates, ethoxylated acrylates and methacrylates, epoxy-lower alkyl acrylates and methacrylates, epoxycycloalkyl-lower alkyl acrylates and methacrylates, hydroxy-substituted lower alkyl-acrylamide and -methacrylamides, hydroxy-substituted lower alkyl vinyl ethers, amino- or hydroxy-substituted styrenes, sodium ethylenesulfonate, sodium styrenesulfonate, 2-acrylamido-2-methylpropanesulfonic acid, acrylic acid, methacrylic acid, amino-lower alkyl and mono-lower alkylamino-lower alkyl acrylates and methacrylates, acryloxy- and methacryloxy-lower alkyl-maleimides and allyl alcohol.
A cross-linkable copolymer comprising a copolymerization product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks in accordance with the Lewis-Mayo equation, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond, wherein the cross-linkable copolymer is water-soluble, and wherein the reactive vinyl monomer (c) is selected from hydroxy-substituted lower alkyl acrylates and methacrylates, hydroxy-substituted lower alkyl-acrylamides and -methacrylamides, hydroxy-substituted lower alkyl vinyl ethers, 2-acrylamido-2-methylpropanesulfonic acid, amino-lower alkyl and mono-lower alkylamino-lower alkyl acrylates and methacrylates, allyl alcohol, epoxy-lower alkyl acrylates and methacrylates, isocyanato-lower alkyl acrylates and methacrylates, vinylically unsaturated carboxylic acids having form 3 to 7 carbon atoms and also the acid chlorides and anhydrides thereof, amino-, hydroxy- or isocyanate-substituted styrenes and epoxycycloalkyl-lower alkyl acrylates and methacrylates.
A cross-linkable copolymer comprising a copolymerization product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks in accordance with the Lewis-Mayo equation, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond, wherein the cross-linkable copolymer is water-soluble wherein the vinyl lactam (a) is a heterocyclic monomer of formula I and the vinyl monomer (b) is selected from unsubstituted or hydroxy-substituted C.sub.1 -C.sub.18 alkyl acrylates and methacrylates, lower alkyl-acrylamides and -methacrylamides and allyl alcohol, and wherein Formula I is ##STR2## wherein R is an alkylene bridge having 2 carbon atoms,
A cross-linkable copolymer comprising a copolymerization product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks in accordance with the Lewis-Mayo equation, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond, wherein the cross-linkable copolymer is water-soluble, wherein the vinyl lactam (a) is a heterocyclic monomer of formula I and the vinyl monomer (c) is selected from amino-lower alkyl and mono-lower alkylamino-lower alkyl acrylates and methacrylates, epoxy-lower alkyl acrylates and methacrylates and vinylically unsaturated carboxylic acids having from 3 to 7 carbon atoms and also the acid chlorides and anhydrides thereof, and wherein Formula I is ##STR3## wherein R is an alkylene bridge having 2 carbon atoms,
A cross-linkable copolymer comprising a copolymerization product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks in accordance with the Lewis-Mayo equation, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond, wherein the cross-linkable copolymer is water-soluble, and wherein the vinyl lactam (a) is a heterocyclic monomer of formula I, the vinyl monomer (b) is selected from unsubstituted or hydroxy-substituted C.sub.1 -C.sub.18 alkyl acrylates and methacrylates, amino-lower alkyl and mono-lower alkylamino-lower alkyl acrylates and methacrylates, and the vinyl monomer (c) is selected from epoxy-lower alkyl acrylates and methacrylates, isocyanato-lower alkyl acrylates and methacrylates and vinylically unsaturated carboxylic acids having from 3 to 7 carbon atoms and also the acid chlorides and anhydrides thereof, and wherein Formula I is ##STR4## wherein R is an alkylene bridge having 2 carbon atoms,
A hydrogel comprising the cross-linked product of a cross-linkable copolymer comprising a copolymerization product of a monomer mixture consisting substantially of a vinyl lactam (a) and at least one further vinyl monomer (b) of a different type selected from the group consisting of hydrophobic, hydrophilic and functional vinyl monomers, wherein the monomers are present in the copolymer in the form of statistically distributed building blocks in accordance with the Lewis-Mayo equation, and, if a functional vinyl monomer is present as a building block in the copolymer, that building block is, where appropriate, modified with a reactive vinyl monomer (c), the reactive vinyl monomer (c) being linked to a building block of a functional vinyl monomer with retention of its vinylic group and with the formation of a covalent bond, wherein the cross-linkable copolymer is water-soluble.
Dependencies are inferred from the claim text.