Inhibitors of microsomal triglyceride transfer protein and method
AssigneeBristol-Myers Squibb Company
InventorsScott A. Biller, John K. Dickson, R. Michael Lawrence, David R. Magnin, Michael A. Poss, Jeffrey A. Robl, Richard B. Sulsky, Joseph A. Tino
Life of this patent
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Abstract
Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein Z, X.sup.1, X.sup.2, x and R.sup.5 are as defined herein.
Claims19
A compound having the structure ##STR265## including the piperidine N-oxide thereof or a pharmaceutically acceptable salt thereof, wherein Z is a bond or S;
- X.sup.1 and X.sup.2 are independently selected from H or halo;
- x is an integer from 2 to 6, (CH.sub.2).sub.x is optionally substituted with 1, 2 or 3 substituents which are the same or different and are alkyl or halo;
- R.sup.5 is heteroaryl, aryl, heterocycloalkyl or cycloalkyl, each R.sup.5 group being optionally substituted with 1, 2, 3 or 4 substituents which may be the same or different, wherein one substituents is optionally attached to a ring carbon in the position adjacent to the carbon linked to ##STR266##
A compound of the structure ##STR281## or a pharmaceutically acceptable salt thereof or the piperidine N-oxide thereof.
A compound having the structure ##STR282## including the piperidine N-oxide thereof or a pharmaceutically acceptable salt thereof,
- R.sup.5 is heteroaryl, aryl, heterocycloalkyl or cycloalkyl, each R.sup.5 group being optionally substituted with 1, 2, 3 or 4 substituents which may be the same or different wherein a substituent on R.sup.5 is adjacent to a ring carbon attached to the ##STR283## group.
Dependencies are inferred from the claim text.