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AssigneeHeska Corporation
InventorsRobert B. Grieve, Keith E. Rushlow, Shirley Wu Hunter, Glenn R. Frank, Gary L. Stiegler
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The present invention relates to flea serine protease and aminopeptidase proteins; to flea serine protease and aminopeptidase nucleic acid molecules, including those that encode such proteins; to antibodies raised against such proteins; and to compounds that inhibit flea serine protease and/or aminopeptidase activities. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitors. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies, and/or inhibitors as well as the use of such therapeutic compositions to protect a host animal from flea infestation.
An isolated and purified flea aminopeptidase protein that comprises an amino acid sequence encoded by a nucleic acid molecule that hybridizes under stringent hybridization conditions with a flea aminopeptidase gene comprising SEQ ID NO:50.
A therapeutic composition that, when administered to an animal, reduces the fecundity of female fleas that feed from said animal, said therapeutic composition comprising an isolated and purified flea aminopeptidase protein that comprises an amino acid sequence encoded by a nucleic acid molecule that hybridizes under stringent hybridization conditions with a flea aminopeptidase gene comprising SEQ ID NO:50.
Dependencies are inferred from the claim text.