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US 5,712,086 AGranted
Process for transfusing cell containing fractions sterilized with radiation and a quencher of type I and type II photodynamic reactions
AssigneeNew York Blood Center, Inc.
InventorsBernard Horowitz, Bolanle Williams, Henrietta Margolis-Nunno, Sing N. Chin
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Abstract
A process is presented for transfusing cells which have been sterilized with radiation and a quencher of type I and type II photodynamic reactions. The cells are removed from a donor and exposed to virucidally effective amount of radiation in the presence of a quencher of type I and type II reactions, or a mixture of a quencher for type I reactions and a quencher of type II reactions. Subsequently, the sterilized cell containing fraction is returned to the donor.
Claims48
A process for transfusing a cell-containing fraction into a donor comprising:
- (a) withdrawing a cell-containing fraction from the donor,
- (b) treating said cell-containing fraction with a virucidally effective amount of artificial irradiation in the presence of (i) a mixture of at least one quencher compound that quenches type I free radical mediated photodynamic reactions and at least one quencher compound that quenches type II reactive forms of oxygen mediated photodynamic reactions or (ii) a quencher compound that quenches both type I and type II reactions or (iii) a mixture of a quencher compound that quenches both type I and type II reactions and an additional quencher compound;
- and
- (c) returning to the donor said treated cell-containing fraction.
1 more element
Dependencies are inferred from the claim text.