# US 5,710,321 A · Process for preparing the cyclohexylamine salt of (+) - threo-2-hydroxy-3-(2'-aminophenylthio) -3-(4"-methoxyphenyl) -propionic acid and of its (-) -antipode"

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- Number: US 5,710,321 A
- Document ID: US5710321A
- Status: Granted
- Kind: A
- Application number: 08/632,077
- Filed: 1996-04-15
- Granted: 1998-01-20
- Earliest claimed: 1995-05-11
- Assignees: F.I.S. Fabbrica Italiana Sintetici S.p.A.
- Inventors: Roberto Bortolaso; Siro Serafini
- Web page: https://patentgrep.com/patent/US5710321A

## CPC

- C07B 57/00: Separation of optically-active compounds
- C07C 211/35: containing only non-condensed rings
- C07C 319/28: Separation; Purification
- C07B 2200/07: Optical isomers
- C07C 2601/14: The ring being saturated
- C07B: GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR (preparation of carboxylic acid esters by telomerisation C07C67/47; telomerisation C08F)
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

The present invention relates to a process for preparing the cyclohexylamine salt of (+)-threo-2-hydroxy-3-(2'-aminophenylthio)-3-(4"-methoxyphenyl)-propionic acid and of its optical (-)-antipode, by starting from the racemate acid by means of a first crystallization from a suitable chiral base and a second crystallization from a cyclohexylamine-containing solvent. Said salt is an intermediate in the synthesis of diltiazem, a well-known calcium-antagonist drug.

## Claims

### Claim 1

A process for preparing the cyclohexylamine salt of (+)-threo-2-hydroxy-3-(2'-aminophenylthio)-3-(4"-methoxyphenyl)-propionic acid and of its (-)-antipode, which comprises the steps of:
a) reacting said threo acid in racemic form with the chiral base (+)-1-cyclohexylethylamine or its (-)-1-cyclohexylethylamine enantiomer to form the corresponding (+)- or (-)-1-cyclohexylethylamine salt thereof, and
b) reacting said cyclohexylethylamine salt formed in step a) with cyclohexylamine to form the corresponding cyclohexylamine salt of (+)- or, respectively, (-)-threo-2-hydroxy-3-(2'-aminophenylthio)-3-(4"-methoxyphenyl)-propionic acid.

### Claim 2 (depends on 1)

The process according to claim 1, characterized in that the (+)-cyclohexylethylamine salt of (+)-threo acid is prepared by reacting said racemic threo acid with (+)-1-cyclohexylethylamine, and in that said (+)-cyclohexylethylamine salt is reacted with cyclohexylamine, thus yielding the cyclohexylamine salt of said (+)-threo acid.

### Claim 3 (depends on 1)

The process according to claim 1, characterized in that the (-)-cyclohexylethylamine salt of (-)-threo acid is prepared by reacting said racemic threo acid with (-)-1-cyclohexylethylamine, and in that said (-)-cyclohexylethylamine salt is reacted with cyclohexylamine, thus yielding the cyclohexylamine salt of said (-)-threo acid.

### Claim 4 (depends on 1)

The process according to claim 1, wherein said racemic threo acid is reacted in alcohol or in an alcohol/water blend with (+)- or (-)-1-cyclohexylethylamine, with the neutralization reaction optionally being brought to completion with an achiral base, wherein the reaction mixture is heated until all of the solids in the reaction mixture have dissolved, wherein the reaction mixture is then cooled until a crystallization of either said (+)-1-cyclohexylethylamine salt or said (-)-1-cyclohexylethylamine salt of said (+)-threo acid or, respectively, of said (-)-threo acid is obtained, wherein said (+)- or (-)-1-cyclohexylethylamine salt is filtered and recrystallized with an alcohol/cyclohexylamine mixture, wherein the resulting reaction mixture is cooled to form a precipitate of the cyclohexylamine salt of (+)-threo or (-)-threo acid, depending on whether (+)-1-cyclohexylethylamine or (-)-1-cyclohexylethylamine was used to form the cyclohexylethylamine salt of (+)-threo acid or (-)-threo acid, and wherein the precipitated solids are filtered and are dried.

### Claim 5

Salt of (+)-, or (-)-cyclohexylethylamine of (+)-threo-2-hydroxy-3-(2'-aminophenylthio)-3-(4"-methoxyphenyl)-propionic acid, or of its (-)-antipode, as an intermediate in the synthesis of the cyclohexylamine salt of said (+)- or (-)-threo acid.