# US 5,710,275 A · 7.beta.-substituted-4-aza-5.alpha.-androstan-3-ones as 5.alpha.-reductase inhibitors

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- Number: US 5,710,275 A
- Document ID: US5710275A
- Status: Granted
- Kind: A
- Application number: 08/341,602
- Filed: 1995-04-03
- Granted: 1998-01-20
- Earliest claimed: 1992-05-20
- Assignees: Merck & Co., Inc.
- Inventors: Raman K. Bakshi; Gary H. Rasmusson; Richard L. Tolman; Gool F. Patel; Georgianna S. Harris; Donald W. Graham; Bruce E. Witzel
- Web page: https://patentgrep.com/patent/US5710275A

## CPC

- C07J 51/00: Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- A61P 13/02: of urine or of the urinary tract, e.g. urine acidifiers
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 17/00: Drugs for dermatological disorders
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07C 59/82: the keto group being part of a ring
- C07C 59/90: containing singly bound oxygen-containing groups
- C07J 73/005: {by nitrogen as hetero atom}
- C07J: STEROIDS (seco-steroids C07C)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

Described are new 7.beta.-substituted 4-aza-5.alpha.-androstan-3-ones and related compounds as 5.alpha.-reductase inhibitors.

## Claims

### Claim 1

A compound of structural formula ##STR266## selected from the group consisting of those in the following table:
______________________________________ R A ______________________________________ ##STR267## CH.sub.3 ##STR268## CH.sub.3 ##STR269## CH.sub.3 ##STR270## CH.sub.3 ##STR271## CH.sub.3 ##STR272## CH.sub.3 ##STR273## ______________________________________

### Claim 2

A compound of structural formula: ##STR274## selected from the group consisting of those in the following table:
______________________________________ R A ______________________________________ CH.sub.3 ##STR275## CH.sub.3 ##STR276## CH.sub.3 ##STR277## ______________________________________