# US 5,710,272 A · 7-methoxymethly-3-methyl-1-(5-oxohexyl)xanthine

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- Number: US 5,710,272 A
- Document ID: US5710272A
- Status: Granted
- Kind: A
- Application number: 08/480,801
- Filed: 1995-06-07
- Granted: 1998-01-20
- Earliest claimed: 1989-12-23
- Assignees: Hoechst Aktiengesellschaft
- Inventors: Werner Aretz; Harald Furrer; Ulrich Gebert; Heinz-Joachim Hinze
- Web page: https://patentgrep.com/patent/US5710272A

## CPC

- C12P 41/002: {by oxidation/reduction reactions}
- A61P 9/00: Drugs for disorders of the cardiovascular system
- C07D 473/06: with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D 473/08: with methyl radicals in positions 1 and 3, e.g. theophylline
- C07D 473/10: with methyl radicals in positions 3 and 7, e.g. theobromine
- C12P 17/18: containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin {(e.g. Rifamycin C12P17/189)}
- Y10S 435/822: using bacteria or actinomycetales
- Y10S 435/911: using fungi
- C12P: FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer C12C; producing vinegar C12J; producing specific peptides or proteins C07K; producing enzymes C12N9/00; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; measuring or testing processes involving enzymes or microorganisms C12Q; measuring or testing processes involving nucleic acid amplification reactions C12Q1/6844; fermentation processes to form a food composition, A21 or A23; compounds in general, see the relevant compound class, e.g. C01, C07)}
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

A Rhodotorula rubra strain has been found which reduces pentoxifylline to 100% to give the S-alcohol. Moreover, other oxoalkylxanthine derivatives can also be convened into the corresponding S-alcohol. The microbiologically obtained S-(+)-enantiomers can then be converted stereoselectively into the respective R-(-)-enantiomers. The corresponding S-alcohols and the R-alcohols obtained by enantioselective inversion of configuration cause an increase in cerebral blood flow.

## Claims

### Claim 1

7-Methoxymethyl-3-methyl-1-(5-oxohexyl)xanthine.