# US 5,710,180 A · Phenethylamine compounds

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- Number: US 5,710,180 A
- Document ID: US5710180A
- Status: Granted
- Kind: A
- Application number: 08/596,197
- Filed: 1996-02-16
- Granted: 1998-01-20
- Earliest claimed: 1996-02-16
- Assignees: SmithKline Beecham Corporation
- Inventors: Siegfried Christensen, IV; Cornelia Jutta Forster
- Web page: https://patentgrep.com/patent/US5710180A

## CPC

- C07C 233/18: having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
- C07C 2601/08: the ring being saturated
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

Substituted phenethylamines of formula (I) useful for treating phosphodiesterase IV related ##STR1## disease states are disclosed herein.

## Claims

### Claim 1

A compound of formula I ##STR8## or a salt thereof, where Q is a radical of formula ##STR9## R.sub.1 is C.sub.7-11 polycycloalkyl, C.sub.3-6 cycloalkyl wherein the cycloalkyl moieties are unsubstituted or substituted by 1 to 3 methyl groups or one ethyl group;
R.sub.2 is --CH.sub.3 or --CH.sub.2 CH.sub.3 unsubstituted or substituted by 1 or more halogens:
R.sub.3 is lower alkyl unsubstituted or substituted by one or more halogens, --CR.sub.4 R.sub.5 OR.sub.4 or --CR.sub.4 (OR.sub.4)CR.sub.4 R.sub.5 OR.sub.4 ;
R.sub.4 and R.sub.5 are independently hydrogen, methyl or ethyl;
R.sub.6 is hydrogen, halogen, --C.sub.1-4 alkyl, halo-substituted C.sub.1-4 alkyl, --CH.dbd.CR.sub.4 R.sub.5, cyclopropyl unsubstituted or substituted by R.sub.4, or --C.tbd.CR.sub.4 ;
R.sub.7 is hydrogen, F, or --CH.sub.3 unsubstituted or substituted by 1 to 3 fluoro groups;
R.sub.8 is H, F, or C.sub.1-2 alkyl optionally substituted by 1 or more fluoro groups;
R.sub.9 is H or unsubstituted or substituted C.sub.1-6 alkyl, wherein optional substituents are from one to three groups independently selected from the group consisting of --CH.sub.3 or --CH.sub.2 CH.sub.3 unsubstituted or substituted by 1 or more halogens;
X.sub.1 is YR.sub.2,
X.sub.2 is O;
X.sub.3 is hydrogen, halogen or X.sub.1 ;
Y is O, S, SO or SO.sub.2 ;
Z is O.

### Claim 2 (depends on 1)

A composition of matter comprising a compound of formula I according to claim 1 in admixture with an excipient.

### Claim 3

A method for treating allergic and inflammatory diseases which comprises administering to a mammal in need thereof an effective amount of a compound of Formula I either alone or in admixture with a pharmaceutically acceptable excipient.