# US 5,710,175 A · Growth stimulating factors

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- Number: US 5,710,175 A
- Document ID: US5710175A
- Status: Granted
- Kind: A
- Application number: 08/627,623
- Filed: 1996-04-04
- Granted: 1998-01-20
- Earliest claimed: 1994-08-03
- Assignees: Cell Therapeutics, Inc.
- Inventors: Edward Nudelman; Sen-Itiroh Hakomori
- Web page: https://patentgrep.com/patent/US5710175A

## CPC

- A61K 31/685: one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
- A61K 31/047: having two or more hydroxy groups, e.g. sorbitol
- A61K 31/075: Ethers or acetals
- A61K 31/08: acyclic, e.g. paraformaldehyde
- A61K 31/121: acyclic
- A61K 31/23: of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K 31/231: having one or two double bonds
- A61K 31/232: having three or more double bonds, e.g. etretinate
- A61K 31/365: Lactones
- A61K 31/445: Non condensed piperidines, e.g. piperocaine
- A61K 31/47: Quinolines; Isoquinolines
- A61K 31/57: substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K 31/7012: Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid (gluconic acid A61K31/191; ascorbic acid A61K31/375)
- A61K 38/13: Cyclosporins
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Alk-1-enyl glycerol derivatives and method of preparing same. The derivatives stimulate cell and tissue growth.

## Claims

### Claim 1

A method for augmenting new blood vessel formation in a patient in need of augmenting healing tissue injury, comprising administering an effective amount of an alk-1-enyl glycerol derivative having the formula: ##STR15## wherein n is 0-23 and X and Y each is H or an acyl group having from 2 to 26 carbon atoms.

### Claim 2 (depends on 1)

The method of claim 1, wherein n is 13 or 15.

### Claim 3 (depends on 1)

The method of claim 1, wherein X is an acyl group and Y is H.

### Claim 4 (depends on 3)

The method of claim 3, wherein said acyl group comprise 20 carbon atoms.

### Claim 5 (depends on 4)

The method of claim 4, wherein said 20 carbon atom acyl group is an arachidonate group.

### Claim 6 (depends on 1)

The method of claim 1, wherein X and Y are acyl groups.

### Claim 7 (depends on 6)

The method of claim 6, wherein Y comprises 20 carbon atoms.

### Claim 8 (depends on 7)

The method of claim 7, wherein said 20 carbon atom acyl group is an arachidonate group.

### Claim 9 (depends on 7)

The method of claim 7, wherein X is an acyl group comprising 16 or 18 carbon atoms.

### Claim 10 (depends on 8)

The method of claim 8, wherein X is an acyl group comprising 16 or 18 carbon atoms.