Tetrazole compound

A tetrazole compound of formula (I):

• ##STR1394## wherein R is a hydrogen atom, ##STR1395## R.sup.1 is 1) C1-8 alkyl,
• 2) C1-8 alkoxy,
• 3) C1-8 alkylamino,
• 4) C1-8 alkylthio,
• 5) Cyc.sup.1, wherein Cyc.sup.1 is a carbocyclic ring or hetero ring, and Cyc.sup.1 is optionally substituted by 1 to 5 substituents selected from a hydrogen atom, C1-4 alkyl, phenyl, C1-4 alkyl substituted by phenyl, a halogen atom, nitro, trifluoromethyl, nitrile, tetrazole, --OR.sup.2, --NR.sup.2 R.sup.3, --SR.sup.2, --COOR.sup.2 or --COR.sup.2, wherein R.sup.2 and R.sup.3 each, independently, is a hydrogen atom, C1-4 alkyl, phenyl or C1-4 alkyl substituted by phenyl, or
• 6) C1-8 alkyl, C1-8 alkoxy, C1-8 alkylamino or C1-8 alkylthio substituted by Cyc.sup.1, m is 0-2,
• with the proviso that,
• (1) when m is O, R.sup.1 is C1-8 alkyl or C1-8 alkoxy, each optionally substituted by Cyc.sup.1, and
• (2) when m is 1, R.sup.1 is C1-8 alkyl, C1-8 alkoxy or C1-8 alkylamino, each optionally substituted by Cyc.sup.1,
• AA.sup.1 is
• 1) a bond
• 2) ##STR1396## or 3) an amino acid, wherein R.sup.4 is
• (1) a hydrogen atom,
• (2) C1-8 alkyl,
• (3) Cyc.sup.2, wherein Cyc.sup.2 is a carbocyclic ring or hetero ring, and Cyc.sup.2 is optionally substituted by 1 to 5 substituents selected from a hydrogen atom, C1-4 alkyl, phenyl, C1-4 alkyl substituted by phenyl, a halogen atom, nitro, trifluoromethyl, nitrile, tetrazole, --OR.sup.5, --NR.sup.5 R.sup.6, --SR.sup.5, --COOR.sup.5 or --COR.sup.5, wherein R.sup.5 and R.sup.6 each, independently, is a hydrogen atom, C1-4 alkyl, phenyl or C1-4 alkyl substituted by phenyl, or
• (4) C1-8 alkyl substituted by a substituent selected from --OR.sup.7, --NR.sup.7 R.sup.8, --SR.sup.7, --COOR.sup.7, --COR.sup.7, --CONH.sub.2, --NR.sup.7 --CO--NR.sup.7 R.sup.8, guanidino or Cyc.sup.2, wherein R.sup.7 and R.sup.8 each, independently, is a hydrogen atom, C1-4 alkyl, phenyl or C1-4 alkyl substituted by phenyl,
• AA.sup.2 is
• 1) a bond
• 2) ##STR1397## or 3) an amino acid, wherein R.sup.9 and R.sup.10 each, independently, is
• (1) a hydrogen atom,
• (2) C1-8 alkyl,
• (3) Cyc.sup.3, wherein Cyc.sup.3 is a carbocyclic ring or hetero ring, and Cyc.sup.3 is optionally substituted by 1 to 5 substituents selected from a hydrogen atom, C1-4 alkyl, phenyl, C1-4 alkyl substituted by phenyl, a halogen atom, nitro, trifluoromethyl, nitrile, tetrazole, --OR.sup.11, --NR.sup.11 R.sup.12, --SR.sup.11, --COOR.sup.11 or --COR.sup.11, wherein R.sup.11 and R.sup.12 each, independently, is a hydrogen atom, C1-4 alkyl, phenyl or C1-4 alkyl substituted by phenyl,
• (4) C1-8 alkyl substituted by a substituent selected from --OR.sup.13, --NR.sup.13 R.sup.14, --SR.sup.13, --COOR.sup.13, --COR.sup.13, --CONH.sub.2, --NR.sup.13 --CO--NR.sup.13 R.sup.14, guanidino or Cyc.sup.3, wherein R.sup.13 and R.sup.14 each, independently, is a hydrogen atom, C1-4 alkyl, phenyl or C1-4 alkyl substituted by phenyl, or
• (5) R.sup.9 and R.sup.10, together, is a C1-6 alkylene or C2-6 alkenylene,
• AA.sup.1 and AA.sup.2, together, may have the formula:
• ##STR1398## in which R.sup.15 and R.sup.16 each, independently, is a hydrogen atom, C1-4 alkyl, phenyl or C1-4 alkyl substituted by phenyl, with the proviso that, C1-4 alkyl or phenyl is optionally substituted by C1-4 alkyl, C1-4 alkoxy, a halogen atom, trifluoromethyl or phenyl,
• R.sup.7 is
• (1) a hydrogen atom,
• (2) C1-8 alkyl,
• (3) Cyc.sup.3, wherein Cyc.sup.3 has the same meaning as hereinbefore defined, or
• (4) C1-8 alkyl substituted by a substituent selected from --OR.sup.13, --NR.sup.13 R.sup.14, --SR.sup.13, --COOR.sup.13, --COR.sup.13, --CONH.sub.2, --NR.sup.13 --CO--NR.sup.13 R.sup.14, guanidino or Cyc.sup.3, wherein R.sup.13 and R.sup.14 have the same meaning as hereinbefore defined,
• q is 2-12,
• with the proviso that, a carbon atom in --(CH.sub.2).sub.q -- is optionally replaced by an oxygen atom, sulfur atom or --NR.sup.18 --, wherein R.sup.18 is a hydrogen atom, C1-4 alkyl, phenyl or C1-4 alkyl substituted by phenyl, or
• two hydrogen atom at ortho positions are replaced by a double bond and Y is ##STR1399## in which R.sup.19 is a hydrogen atom, C1-8 alkyl, phenyl or C1-4 alkyl substituted by phenyl,
• n is 1-4, ##STR1400## is a carbocyclic ring or hetero ring, with the proviso that, ##STR1401## is bonded directly to the carbon atom on a tetrazole ring, R.sup.20 is
• 1) a hydrogen atom,
• 2) C1-4 alkyl,
• 3) a halogen atom,
• 4) nitro,
• 5) trifluoromethyl,
• 6) nitrile,
• 7) --OR.sup.22,
• 8) --NR.sup.22 R.sup.23,
• 9) --SR.sup.22,
• 10) Cyc.sup.4, wherein Cyc.sup.4 is a carbocyclic ring or hetero ring, and Cyc.sup.4 is optionally substituted by 1 to 5 substituents selected from a hydrogen atom, C1-4 alkyl, phenyl, C1-4 alkyl substituted by phenyl, a halogen atom, nitro, trifluoromethyl, nitrile, tetrazole, --OR.sup.24, --NR.sup.24 R.sup.25, --SR.sup.24, --COOR.sup.24 or --COR.sup.24, wherein R.sup.24 and R.sup.25 each, independently, is a hydrogen atom, C1-4 alkyl, phenyl or C1-4 alkyl substituted by phenyl,
• 11)--COOR.sup.26 or
• 12)--COR.sup.27,
• R.sup.22 and R.sup.23 each, independently, is a hydrogen atom, C1-4 alkyl, phenyl or C1-4 alkyl substituted by phenyl,
• R.sup.26 is a hydrogen atom, C1-4 alkyl, trihalomethyl, C1-4 alkyl substituted by trihalomethyl, Cyc.sup.4, wherein Cyc.sup.4 has the same meaning as hereinbefore defined, C 1-4 alkyl substituted by Cyc.sup.4,
• R.sup.27 is
• (1) a hydrogen atom,
• (2) C1-4 alkyl,
• (3) --NR.sup.28 R.sup.29,
• (4) phenyl,
• (5) C1-4 alkyl substituted by phenyl, ##STR1402## wherein R.sup.28 and R.sup.29 each, independently, is a hydrogen atom, C1-4 alkyl, phenyl or C1-4 alkyl substituted by phenyl, or
• R.sup.28 and R.sup.29, together, is a hetero ring,
• R.sup.3.degree. is a hydrogen atom, C1-8 alkyl, Cyc.sup.2, wherein Cyc.sup.2 has the same meaning as hereinbefore defined, or C1-8 alkyl substituted by a substituent selected from --OR.sup.7, --NR.sup.7 R.sup.8, --SR.sup.7, --COOR.sup.7, --COR.sup.7, --CONH.sub.2, --NR.sup.7 --CO--NR.sup.7 R.sup.8, guanidino or Cyc.sup.2, wherein Cyc.sup.2, R.sup.7 and R.sup.8 have the same meaning as hereinbefore defined, or
• R.sup.30 and one of R.sup.28 or R.sup.29, together, is --(CH.sub.2).sub.q --, wherein --(CH.sub.2).sub.q -- has the same meaning as hereinbefore defined, and
• p is 1-5;
• or a non-toxic salt thereof, an acid addition salt thereof or a hydrate thereof.