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US 5,709,879 AGranted
Vaccine compositions containing liposomes
AssigneeChiron Corporation
InventorsGail L. Barchfeld, Gary Ott, Gary A. Van Nest
Life of this patent
Estimating the term…
Abstract
A vaccine composition, comprising an antigenic substance in association with a liposome and an oil-in-water emulsion comprising a muramyl peptide, a metabolizable oil, and optionally an additional emulsifying agent. The two components of the adjuvant (i.e., the liposome/antigen component and the emulsion component) act together to produce high levels of immune response.
Claims37
A vaccine composition, comprising:
- (1) an immunostimulating amount of an antigenic substance in association with liposomes, wherein the liposomes have a net negative charge;
- and
- (2) an oil-in-water emulsion comprising a metabolizable oil in a continuous phase surrounding said liposomes, said emulsion being present in an amount sufficient to increase immune responce relative to that of said antigenic substance and liposomes in the absence of said emulsion.
A method of stimulating an immune response in a host animal, comprising:
- administering an effective amount of a protective antigen to said animal in association with liposomes wherein the liposomes have a net negative charge, wherein said liposomes and said antigen or antigens are administered in admixture with a continuous aqueous phase containing an oil-in-water emulsion, wherein said oil in said emulsion is a metabolizable oil and said emulsion is present in an amount sufficient to increase immune response relative to that of said antigen and liposomes in the absence of said emulsion.
Dependencies are inferred from the claim text.