Device for local drug delivery and methods for using the same
AssigneeEmory University
InventorsStephen R. Hanson, Neal A. Scott, Spencer B. King, III, Laurence A. Harker
Life of this patent
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Abstract
A device for the local delivery of a substance into a natural tissue conduit in the mammalian body. The device has a substance delivery segment which provides a means for locally delivering a substance into the boundary layer of fluid flowing through the conduit without disrupting the fluid flow therethrough. For example, an indwelling catheter is provided for endovascular delivery of a substance locally to a targeted treatment area. Also provided are methods of locally delivering a substance into a natural tissue conduit in the mammalian body utilizing the device of the present invention.
Claims48
A device for the local delivery of a substance at a predetermined site in a natural tissue conduit in the mammalian body, the conduit having a luminal surface defining a lumen, comprising:
- a) an elongated flexible tube of a preselected length and diameter having an external surface, a proximal end, an opposite distal end, and a lumen extending longitudinally therethrough interconnecting the proximal and distal ends with the proximal end defining an opening therethrough, the tube having a substance delivery segment adjacent the distal end and defining a plurality of substance delivery holes through the external surface which are in fluid communication with the lumen of the tube, the substance delivery segment being moveable among a first rest position wherein it has a first shape, a second position wherein it has a second shape, and a third operative position wherein it has a third shape, the third position being intermediate the first and second positions;
- b) means for moving the substance delivery segment from its first position to its second position, the substance delivery segment tending to return to the first position when the moving means is no longer applied to the substance delivery segment;
- and
- c) means for introducing the substance into the lumen of the tube for delivery into the natural tissue conduit.
A method for providing prolonged localized delivery of a biologically active substance directly into the boundary layer of blood flowing through a predetermined site within a blood vessel without substantially compromising central blood flow through the vessel, the blood vessel having a luminal surface defining a lumen, comprising the steps of:
- a) placing a substance delivery device that is adapted to provide prolonged localized delivery of a therapeutic agent directly into the boundary layer of blood flowing through a predetermined site without substantially compromising central blood flow through the vessel in the lumen of the blood vessel adjacent the predetermined site;
- and
- b) delivering a substance to the predetermined site via the substance delivery device.
A device for the local delivery of a biologically active substance at a predetermined site in a natural tissue conduit in the mammalian body, the conduit having a luminal surface defining a lumen, comprising:
- a) an elongated flexible tube of a preselected length and diameter having an external surface, a proximal end, an opposite distal end, and a lumen extending longitudinally therethrough interconnecting the proximal and distal ends with the proximal end defining an opening therethrough, the tube having a substance delivery segment adjacent the distal end and defining a plurality of substance delivery holes through the external surface which are in fluid communication with the lumen of the tube, the substance delivery segment being movable between a resting shape wherein the substance delivery segment comprises a plurality of spiral turns about the longitudinal axis of the device such that the substance delivery segment forms a hollow coil having a first resting diameter and an operative shape wherein the substance delivery segment comprises a plurality of spiral turns about the longitudinal axis of the device such that the substance delivery segment forms a hollow coil having a second operative diameter;
- and,
- b) means for introducing the substance into the lumen of the tube for delivery into the natural tissue conduit.
Dependencies are inferred from the claim text.