Tissue formation by injecting a cell-polymeric solution that gels in vivo
AssigneeMassachusetts Institute of Technology
InventorsLinda Griffith-Cima, Anthony Atala, Charles A. Vacanti, Keith T. Paige
Life of this patent
Estimating the term…
Loading patent…
AssigneeMassachusetts Institute of Technology
InventorsLinda Griffith-Cima, Anthony Atala, Charles A. Vacanti, Keith T. Paige
Estimating the term…
A cell-polymeric solution is injected into an animal where the polymer crosslinks to form a polymeric hydrogel containing dispersed cells and the cells form new tissue in the animal. The polymer is biodegradable and is a natural polymer such as alginate or a synthetic polymer. The cells are chondrocytes, osteoblasts, muscle cells, fibroblasts or cells acting primarily to synthesize, secret or metabolize materials. Crosslinking of the polymer results from using cations or anions, altering the pH or changing the temperature. A polyion such as polyethyleneimine or polylysine can be added before injection to stabilize the polymeric hydrogel. A kit for tissue formation is provided by combining the cell-polymeric solution with a means for injecting the solution into an animal.
A method for injecting a cell suspension into an animal to form tissue within the animal comprising
A kit for formation of tissue at a site in a patient comprising
Dependencies are inferred from the claim text.