Method and apparatus for predicting the presence of congenital and acquired imbalances and therapeutic conditions

An apparatus for performing at least one time-dependent measurement on an unknown sample to derive at least one time-dependent measurement profile, and predicting the presence of at least one congenital or acquired imbalance or therapeutic condition associated with thrombosis/hemostasis from the at least one time-dependent measurement profile, comprising:

• means for performing at least one time-dependent measurement on an unknown sample and measuring a respective property over time so as to derive a time-dependent measurement profile;
• means for defining a set of a plurality of predictor variables which sufficiently define the data of the time-dependent measurement profile;
• means for deriving a model that represents the relationship between the congenital or acquired imbalance or therapeutic condition, and the set of predictor variables;
• and
• means for utilizing the model of step c) to predict the existence of the congenital or acquired imbalance or therapeutic condition in the unknown sample;
• wherein said set of predictor variables includes a plurality of:
• a minimum of the first derivative of the profile, a time index of the minimum of the first derivative, a minimum of the second derivative of the profile, a time index of the minimum of the second derivative, a maximum of the second derivative of the profile, a time index of the maximum of the second derivative, an overall change in the coagulation parameter during the time-dependent measurement on the unknown sample, a clotting time, a slope of the profile prior to clot information, and a slope of the profile after clot formation.