# US 5,708,138 A · Immunoreactive peptides of apo(a)

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- Number: US 5,708,138 A
- Document ID: US5708138A
- Status: Granted
- Kind: A
- Application number: 08/457,449
- Filed: 1995-06-01
- Granted: 1998-01-13
- Earliest claimed: 1993-12-21
- Assignees: PerImmune Holdings, Inc.
- Inventors: W. C. Taddei-Peters; Sandra M. Butler
- Web page: https://patentgrep.com/patent/US5708138A

## CPC

- C07K 16/18: against material from animals or humans
- C07K 14/775: Apolipopeptides
- A61K 39/00: Medicinal preparations containing antigens or antibodies (materials for immunoassay G01N33/53)
- C07K 2317/34: Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The present invention relates to peptides immunoreactive with anti-apolipoprotein(a) antibodies and to their use in raising monoclonal and polyclonal antibodies, in immunoassays and of their corresponding oligonucleotides as probes and primers in nucleic acid methodology,

## Claims

### Claim 1

A peptide that contains less than the entire sequence of apo(a) and that has a sequence corresponding to an amino acid sequence found in human and Old World monkey Apo(a) and that has at least one amino acid that is different; from the corresponding position in human and Old World monkey plasminogen, and wherein said peptide comprises an amino acid sequence selected from the group consisting of SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:14, SEQ ID NO:16, SEQ ID NO:18, SEQ ID NO:20 and SEQ ID NO:22, or portions thereof that are capable of raising antibodies that react with apo(a) and not plasminogen.

### Claim 2 (depends on 1)

A peptide according to claim 1, which has an amino acid sequence selected from the group consisting of SEQ ID NO:24, SEQ ID NO:26, SEQ ID NO:28, SEQ ID NO:30, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:36, SEQ ID NO:38 and SEQ ID NO:40.

### Claim 3 (depends on 1)

A peptide according to claim 1, which has the amino acid sequence of SEQ ID NO:2, or a portion thereof that is capable of raising antibodies that react with apo(a) and not plasminogen.

### Claim 4 (depends on 3)

A peptide according to claim 3, which has the amino acid sequence of SEQ ID NO:24.