# US 5,708,038 A · Method of using aloe vera as a biological vehicle > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 5,708,038 A - Document ID: US5708038A - Status: Granted - Kind: A - Application number: 08/662,654 - Filed: 1996-06-13 - Granted: 1998-01-13 - Earliest claimed: 1996-06-13 - Assignees: Univera Pharmaceuticals, Inc. - Inventors: Robert H. Davis - Web page: https://patentgrep.com/patent/US5708038A ## CPC - A61K 31/568: substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone - A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)} - A61K 31/565: not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol - A61K 47/46: Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) ## Abstract The present invention provides a method for using Aloe vera as a biological vehicle for the delivery of drugs. In one embodiment Aloe vera is used as a biological vehicle to deliver the estrogen, .beta.-estradiol and the androgen, testosterone propionate. The present invention also provides a method of treating symptoms and diseases mediated by hormonal deficiencies or amenable to treatment by hormones using Aloe vera as a biological vehicle. ## Claims ### Claim 1 A method of using Aloe vera as a vehicle for the delivery of estrogenic hormones comprising administration of the estrogenic hormone in combination with Aloe vera. ### Claim 2 (depends on 1) The method of claim 1 wherein the Aloe vera is derived from the Aloe barbadensis plant. ### Claim 3 (depends on 1) The method of claim 1 wherein the estrogenic hormone is selected from the group consisting of .beta.-estradiol, estrone, estriol, or derivatives thereof. ### Claim 4 (depends on 3) The method of claim 3 wherein the estrogenic hormone is an esterified derivative of .beta.-estradiol. ### Claim 5 (depends on 4) The method of claim 4 wherein the esterified derivative of .beta.-estradiol is selected from the group consisting of estradiol benzoate, estradiol cypionate, estradiol dipropionate, estradiol enanthate, estradiol ethynyl, estradiol undecylate, or estradiol valerate. ### Claim 6 A method of using Aloe vera as a vehicle for the delivery of androgenic hormones comprising administration of the androgenic hormone in combination with Aloe vera. ### Claim 7 (depends on 6) The method of claim 6 wherein the Aloe vera is derived from the Aloe barbadensis plant. ### Claim 8 (depends on 6) The method of claim 6 wherein the androgenic hormone is selected from the group consisting of methyltestosterone, testosterone or derivatives thereof. ### Claim 9 (depends on 8) The method of claim 8 wherein the androgenic hormone is an esterified derivative of testosterone. ### Claim 10 (depends on 9) The method of claim 9 wherein the esterified derivative of testosterone is selected from the group consisting of testosterone cyclopentylpropionate (cipionate), testosterone enanthate (heptanoate), testosterone ethisterone (ethinyl), testosterone ketolaurate, testosterone phenylacetate or testosterone propionate. ### Claim 11 A method for treating estrogenic deficiencies and conditions amenable to treatment by estrogens comprising administering to a patient in need thereof a therapeutically effective amount of an estrogenic hormone in combination with Aloe vera. ### Claim 12 (depends on 11) The method of claim 11 wherein the Aloe vera is derived from the Aloe barbadensis plant. ### Claim 13 (depends on 11) The method of claim 11 wherein the estrogenic hormone is selected from the group consisting of .beta.-estradiol, estrone, estriol, or derivatives thereof. ### Claim 14 (depends on 13) The method of claim 13 wherein the estrogenic hormone is an esterified derivative of .beta.-estradiol. ### Claim 15 (depends on 14) The method of claim 14 wherein the esterified derivative of .beta.-estradiol is selected from the group consisting of estradiol benzoate, estradiol cypionate, estradiol dipropionate, estradiol enanthate, estradiol ethynyl, estradiol undecylate, or estradiol valerate. ### Claim 16 (depends on 11) The method of claim 11 wherein the condition amenable to treatment by estrogen hormones is selected from the group consisting of ovarian disorders, osteoporosis, coronary disorders, and problems associated with menopause or cancer. ### Claim 17 A method for treating androgenic deficiencies and conditions amenable to treatment by androgens comprising administering to a patient in need thereof a therapeutically effective amount of an androgen hormone in combination with Aloe vera. ### Claim 18 (depends on 17) The method of claim 17 wherein the Aloe vera is derived from the Aloe barbadensis plant. ### Claim 19 (depends on 17) The method of claim 17 wherein the androgenic hormone is selected from the group consisting of methyltestosterone, testosterone or derivatives thereof. ### Claim 20 (depends on 18) The method of claim 18 wherein the androgenic hormone is an esterified derivative of testosterone. ### Claim 21 (depends on 20) The method of claim 20 wherein the esterified derivative of testosterone is selected from the group consisting of testosterone cyclopentylpropionate (cipionate), testosterone enanthate (heptanoate), testosterone ethisterone (ethinyl), testosterone ketolaurate, testosterone phenylacetate or testosterone propionate. ### Claim 22 (depends on 18) The method of claim 18 wherein the condition amenable to treatment by androgen hormones is selected from the group consisting of hypogonadism or cancer. ### Claim 23 A method for treating conditions amenable to treatment by an estrogenic hormone comprising administering to a patient in need thereof an efficacious amount of a composition comprising an estrogen and Aloe vera. ### Claim 24 (depends on 23) The method of claim 23 wherein the amount of Aloe vera in the composition is between 25 and 300 mg/kg of body weight. ### Claim 25 (depends on 23) The method of claim 23 wherein the Aloe vera is derived from the Aloe barbadensis plant. ### Claim 26 (depends on 23) The method of claim 23 wherein the estrogenic hormone is selected from the group consisting of .beta.-estradiol, estrone, estriol, or derivatives thereof. ### Claim 27 (depends on 23) The method of claim 23 wherein the estrogenic hormone is an esterified derivative of .beta.-estradiol. ### Claim 28 (depends on 27) The method of claim 27 wherein the esterified derivative of .beta.-estradiol is selected from the group consisting of estradiol benzoate, estradiol cypionate, estradiol dipropionate, estradiol enanthate, estradiol ethynyl, estradiol undecylate, or estradiol valerate. ### Claim 29 A method for treating conditions amenable to treatment by an androgenic hormone comprising administering to a patient in need thereof an efficacious amount of a composition comprising an androgen and Aloe vera. ### Claim 30 (depends on 29) The method of claim 29 wherein the amount of Aloe vera in the composition is between 25 and 300 mg/kg. ### Claim 31 (depends on 29) The method of claim 29 wherein the Aloe vera is derived from the Aloe barbadensis plant. ### Claim 32 (depends on 29) The method of claim 29 wherein the androgenic hormone is selected from the group consisting of methyltestosterone, testosterone or derivatives thereof. ### Claim 33 (depends on 29) The method of claim 29 wherein the androgenic hormone is an esterified derivative of testosterone. ### Claim 34 (depends on 33) The method of claim 33 wherein the esterified derivative of testosterone is selected from the group consisting of testosterone cyclopentylpropionate (cipionate), testosterone enanthate (heptanoate), testosterone ethisterone (ethinyl), testosterone ketolaurate, testosterone phenylacetate or testosterone propionate.